Routine prescription of a hypnotic medication does not appear to substantially reduce suicidal ideation in depressed outpatients with insomnia, but coprescription of such drug during antidepressant initiation may help suicidal outpatients, particularly those with severe insomnia, suggest the results of a study.
Specific functional network-based moderators of treatment outcome have been identified, and these involve brain networks affected by major depression, reports a study. In addition, a favourable response for an antidepressant medication appears to be influenced by functional connectivity patterns of brain regions between and within networks.
A study of 74 Swedish twins and triplets discordant for attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) and other neurodevelopmental diagnoses identified a consistent reduction in regularity and complexity of cobalt, lead and vanadium cycles in individuals with ADHD.
Depressive symptoms appear to be common in middle aged and older Chinese adults, particularly in women and those residing in rural areas, according to a secondary analysis of a prospective cohort study. On the other hand, longer sleep duration and better self-perceived health status confer protective benefits.
Generalized anxiety symptoms commonly occur after stroke or transient ischaemic attack and are associated with younger age and greater depressive symptoms, and these relationships persist even among patients without severe comorbid depressive symptoms, as reported in a recent study.
Mental health smartphone applications (apps) help improve a range of outcomes, including depressive and generalized anxiety symptoms and stress levels, with small-to-moderate effect sizes, according to a meta-analysis.
Women who show symptoms of postpartum depression in the first or sixth month after delivery tend to encounter difficulty caring for their infants, a recent study suggests. Left untreated, the mood disorder can prevent the formation of a critical bond between mother and child.
Several anti-inflammatory drugs, including aspirin, oestrogens, minocycline and N-acetylcysteine, appear to help mitigate symptom severity in patients with schizophrenia, according to a systematic review and meta-analysis.
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Supplementation with oral nano vitamin D appears to moderate disease activity and severity grade of patients with active ulcerative colitis (UC), suggests a study, adding that this association is more evident in those achieving a target vitamin D level of 40 ng/mL.