Adolescents with disruptive behaviour disorder (DBD), with and without callous-unemotional (CU) traits, have reduced dorsal anterior cingulate cortex (ACC) activation during reward anticipation relative to typically developing youths, a study has shown.
Intravenous ketamine is well tolerated and demonstrates significant short-term efficacy in reducing depressive symptoms in adolescents with treatment-resistant depression as compared with an active placebo, according to a recent study.
Among the Chinese, suicide appears to be more likely among men, the elderly, and people who are single, a recent study has found. Similarly, those with major physical illnesses or lifetime mental disorders are also more likely to die by suicide.
A re-evaluation of psychiatric treatment is needed for pregnant women treated with antidepressant, suggests a recent study, noting the necessity for focusing on obstetric complications for severely depressed women.
While early-phase clinical trials may demonstrate substantial levels of overall response rates in patients with relapsed/refractory multiple myeloma (RRMM), high heterogeneity of evidence prevents the accurate assessment of clinical benefit before patient participation, reports a recent meta-analysis.
The COVID-19 vaccine AZD1222 by AstraZeneca and the University of Oxford was 79 percent effective overall in preventing symptomatic infections – higher than observed in previous clinical trials of the vaccine – at the interim analysis of a US phase III trial.
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.