prostate%20cancer
PROSTATE CANCER

Prostate cancer is the cancer that occurs in the male's prostate.

It is the most common cancer in men >50 years of age.

Signs and symptoms include weak urinary stream, polyuria, nocturia, hematuria, erectile dysfunction, pelvic pain, back pain, chest pain, lower extremity weakness or numbness and loss of bowel or bladder control.

Introduction

  • One of the most common cancers in men >50 years of age 

Signs and Symptoms

  • Weak urinary stream
  • Polyuria, nocturia
  • Hematuria
  • Erectile dysfunction
  • Pelvic pain, back pain, chest pain
  • Lower extremity weakness or numbness
  • Loss of bladder or bowel control

Risk Factors

  • Age (increased risk in men >50 years old)
  • Positive family history (1st-degree relatives and relatives diagnosed with prostate cancer at an early age doubles the risk)
  • Ethnicity (African-American, Caribbean men of African ancestry)
  • Chemical exposures (toxic combustion products)
  • Genetic mutations: Breast cancer susceptibility gene 1 (BRCA1), breast cancer susceptibility gene 2 (BRCA2) mutations, deoxyribonucleic acid (DNA) mismatch repair genes [MutS Homolog 2 (MSH2), MutL Homolog 1 (MLH1), Lynch syndrome], insulin-like growth factor-1 (IGF-1)
  • Other risk factors under research include a positive medical history of inflammation of the prostate gland [eg prostatitis, STDs, proliferative inflammatory atrophy (PIN)] and vasectomy
Editor's Recommendations
Most Read Articles
Tristan Manalac, 6 days ago
Gestational exposure to grain products fortified with folic acid appears to be linked to a lower risk of psychosis in offspring, according to a recent study.
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
3 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 4 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.