Primary open-angle glaucoma (POAG) is a chronic, progressive, usually bilateral disease of the eye with an insidious onset.
It is most often characterized by optic nerve damage, defects in the retinal fiber layer and subsequent visual field loss in the absence of underlying ocular disease or congenital abnormalities.
It is generally asymptomatic until it has caused a significant loss of visual field.
Occasionally, patients with very high intraocular pressure may complain of nonspecific headache, discomfort, intermittent blurring of vision or even halos caused by corneal edema.
Once-daily dosing of the Rho kinase inhibitor netarsudil is not inferior to twice-daily timolol in terms of lowering intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, while having tolerable adverse events, according to the results of the phase III ROCKET-4 trial.
A new study from the UK has suggested that patients recently diagnosed with ocular hypertension or open angle glaucoma (OAG) could derive greater benefit from undergoing selective laser trabeculoplasty (SLT) rather than being treated with intraocular pressure-reducing eye drops.
New drug applications approved by US FDA as of 01 - 15 March 2019 which includes New Molecular Entities (NMEs) and new biologics. It
does not include Tentative Approvals. Supplemental approvals may have
occurred since the original approval date.
Patients newly diagnosed with glaucoma are highly likely to report depressive symptoms, with risk factors including young age and female sex, among others, a study has found. Depressive symptomatology appears to decrease considerably 1 year after treatment but remains elevated in patients with impaired vision-related quality of life.
applications approved by US FDA as of 1 - 15 September 2018 which includes New Molecular Entities (NMEs) and new
biologics. It does not include Tentative Approvals. Supplemental approvals
may have occurred since the original approval date.
Long-term treatment with memantine is well tolerated but does not effectively prevent glaucomatous progression in patients with open-angle glaucoma (OAG), according to the results of two phase III trials.
Plasma sex hormone concentration overall does not have any effect on the risk of primary open-angle glaucoma (POAG) in postmenopausal women, according to a study. However, elevated testosterone levels appear to be associated with POAG and higher intraocular pressure (IOP).
The topical investigational drug netarsudil 0.02% has the potential to become a useful addition to the armamentarium of ocular hypotensive medications, with data from two randomized noninferiority clinical trials showing that the drug is effective and well tolerated in the treatment of patients with ocular hypertension and open-angle glaucoma.
Extremes in systolic ocular perfusion pressure (OPP) and low systolic blood pressure (BP) levels appeared to raise the risk of primary open-angle glaucoma (POAG) in an Asian population, according to findings from the SEED* study.