primary%20biliary%20cirrhosis
PRIMARY BILIARY CIRRHOSIS

Primary biliary cirrhosis is chronic, progressive, autoimmune, cholestatic liver disease more common in middle-aged women. It is characterized by destruction of small to medium bile ducts, leading to cholestasis and frequently, end-stage liver disease.
Diagnostic features are chronic biochemical cholestasis, presence of antimitochondrial antibodies and the characteristic liver biopsy findings.
At present, the diagnosis is most often made in an asymptomatic patient who presents with abnormal lab results on a routine checkup or as part of workup for an associated illness.


 

Surgical Intervention

Liver Transplantation 

  • Liver transplantation is the only life-saving procedure for patients w/ progressive primary biliary cirrhosis (PBC) & consequent liver failure
    • Increasing bilirubin & decreasing albumin levels & a prolonged prothrombin time are signs of disease progression
    • Model for End-stage Liver Disease (MELD) score of 315 & >7.8 from the updated Mayo Clinic Natural History Model for primary biliary cirrhosis (PBC)
  • Consider liver transplantation in refractory ascites, recurrent spontaneous bacterial peritonitis, recurrent variceal bleeding, hepatic coma, hepatocellular carcinoma or hepatorenal syndrome type I
    • Uncontrollable pruritus, chronic fatigue & severe osteoporosis may also be indications for liver transplantation
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
13 Mar 2017
The serum pepsinogen test—which is relatively simple, inexpensive, sensitive and specific—is a potentially viable method for the screening and detection of Kazakh early gastric cancer, a new study claims.
24 Apr 2017

Helicobacter pylori (H. pylori) infection is associated with conditions such as gastritis, peptic ulcer, gastric cancer, and certain types of lymphoma. A common presenting complaint among all these H. pylori-related illnesses is dyspepsia. Dr Desmond Wai from the Desmond Wai Liver and Gastrointestinal Diseases Centre, Mount Elizabeth Novena Specialist Centre, Singapore, speaks on the important role general practitioners (GPs) play in recognizing, diagnosing, and treating H. pylori.

Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.