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PRIMARY BILIARY CHOLANGITIS

Primary biliary cholangitis (formerly primary biliary cirrhosis) is a chronic, progressive, autoimmune, cholestatic liver disease more common in middle-aged women. It is characterized by destruction of small to medium bile ducts leading to cholestasis and frequently, end-stage liver disease.
Diagnostic features are chronic biochemical cholestasis, presence of antimitochondrial antibodies and the characteristic liver biopsy findings.


 

Differential Diagnosis

  • Alternative diagnoses include primary sclerosing cholangitis, obstructive jaundice, drug-induced liver injury, AIH, hyperthyroidism, bone lesions, sarcoidosis
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