Premenstrual Syndrome (PMS)

• PMS is a group of recurrent mild to moderate physical and emotional symptoms occurring during the late luteal phase of the ovulatory cycle that do not usually interfere with the patient’s usual level of function
  • Occurs in approximately 75% of women of reproductive age, among whom 20-50% report moderate to severe symptoms

Premenstrual Dysphoric Disorder (PMDD)

• PMDD is a cyclical disorder presenting with distressing mood and behavioral symptoms that occur during the late luteal phase of the ovulatory cycle; it is a severe form of premenstrual syndrome (PMS)
• PMDD results in considerable impairment of the patient’s personal functioning
  • Occurs in approximately 5% of women of reproductive age

• Allergies
• Anemia
• Asthma
• Autoimmune or collagen vascular disorders
• Chronic fatigue syndrome
• Endometriosis
• Endocrine disorders [diabetes mellitus (DM), hypothyroidism]
• Epilepsy
• Hyperprolactinemia
• Irritable bowel syndrome
• Migraine
• Panhypopituitarism
• Polycystic ovarian disease

The following psychiatric conditions may mimic PMDD with premenstrual exacerbation:

• Anxiety disorders
• Bipolar disorder
• Bulimia
• Cyclothymic disorder
• Depression
• Dysthymic disorder
• Posttraumatic stress disorder
• Psychosocial (current victim of physical abuse or history of sexual abuse)
• Panic disorder