Premature ejaculation is a male sexual dysfunction characterized by short, easily stimulated ejaculation that occurs always or nearly always before or within one minute of vaginal penetration.
It is involuntarily controlled and causes negative personal consequences like distress, frustration and avoidance of sexual intimacy.
Exact etiology and risk factors are unknown.
Short, easily stimulated ejaculation that occurs always or nearly always before or within about 1 minute of vaginal penetration or a clinically significant and bothersome reduction in latency time, often to about 3 minutes or less
Either present from the first sexual experience or following a new bothersome change in ejaculatory latency
Causes negative personal consequences eg distress, bother, frustration, avoidance of sexual intimacy and interpersonal difficulty
Most common male sexual dysfunction with prevalence not affected by age
More common in younger men
Unknown exact etiology with few data to support the following suggested biological and psychological hypotheses including:
5-HT receptor dysfunction
Risk factors include:
Genetic influences (lifelong PE)
Prostatic inflammation and chronic bacterial prostatitis (acquired PE)
Hormonal aberrations or thyroid hormone disorders
Poor overall health status and obesity
Psychological factors that may precipitate PE are historical
factors (eg sexual abuse, attitude towards sex in the home), individual
psychological factors (eg body image, depression, performance anxiety)
or relationship factors (eg intimacy, anger)
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa,
08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.