Premature ejaculation is a male sexual dysfunction characterized by short, easily stimulated ejaculation that occurs always or nearly always before or within one minute of vaginal penetration.
It is involuntarily controlled and causes negative personal consequences like distress, frustration and avoidance of sexual intimacy.
Exact etiology and risk factors are unknown.
Transcutaneous electrical stimulation to the perineum may help increase the time taken to ejaculate during masturbation in men with premature ejaculation, without adverse consequences, as shown in a study.
Use of clomipramine as an on-demand treatment of premature ejaculation is well tolerated and effective, with the results of a phase III study showing increased ejaculation time during vaginal penetration.
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.