Postpartum hemorrhage is defined as blood loss of ≥500 mL for vaginal delivery after completion of the 3rd stage of labor while for cesarean delivery, the cut-off is 1000 mL.
It may present as either early (primary) or late (secondary) postpartum hemorrhage.
Postpartum hemorrhage may produce hemodynamic instability during the 1st 24 hours after delivery.
Immediate administration of the antifibrinolytic tranexamic acid increased the likelihood of survival in patients with acute severe haemorrhage, with efficacy reducing with every 15-minute delay in treatment, according to a large study.
Women given tranexamic acid within three hours of giving birth appear to have a reduced risk of death due to postpartum haemorrhage (PPH), according to findings of the large, multinational WOMAN* trial.
Women with platinum-sensitive ovarian cancer with germline BRCA mutations who relapsed after previously receiving ≥2 lines of chemotherapy demonstrated better objective response rates (ORRs) and progression-free survival (PFS) following treatment with olaparib than platinum-based chemotherapy, according to results of the SOLO3* trial.