Polycystic ovarian syndrome (PCOS) is the accumulation of underdeveloped follicles in the ovaries due to anovulation. It is is characterized by menstrual abnormalities and clinical or biochemical features of hyperandrogenism.
It results mainly from abnormal steroidogenesis that may be caused by insulin resistance leading to hyperinsulinemia.
There is increased sensitivity to androgens and the majority of women have elevated androgen levels.
Sedentary behaviour remains extremely prevalent among overweight or obese women with polycystic ovary syndrome (PCOS), with a recent study reporting that only one in two women meets physical activity (PA) levels recommended for weight loss.
Middle-aged women with polycystic ovary syndrome (PCOS) exhibit only a moderately unfavourable cardiometabolic profile despite having an increased body mass index (BMI) and waist circumference, as reported in a study.
In the management of women with polycystic ovary syndrome (PCOS) and obesity, rosiglitazone monotherapy or in combination with low-dose metformin plus lifestyle modification should be recommended to those with abnormal lipid profiles, according to the results of a trial.
Hyperinsulinaemia and insulin resistance appear to exacerbate phenotypic characteristics, reproductive endocrine disorders, and glucose and lipid metabolic dysfunction in polycystic ovary syndrome (PCOS) patients and therefore lead to reduced fertility in these women, a study has found.
Use of oral contraceptive agents in combination with metformin or lifestyle changes appears to effectively reduce the adverse impact of polycystic ovary syndrome (PCOS) on glucose and lipid metabolism in overweight women, according to the results of a network meta-analysis.
The sodium‐glucose‐cotransporter‐2 inhibitor empagliflozin yields beneficial effects on weight anthropometric parameters and body composition—including weight, body mass index, waist and hip circumference, and total body fat—that are greater than those achieved with metformin in overweight and obese women with polycystic ovary syndrome (PCOS), a study has shown.
Infants born to mothers with polycystic ovary syndrome (PCOS) are less likely to be large for gestational age, according to data from the SCOPE* cohort study. Moreover, PCOS does not carry an increased risk of pregnancy complications in women following a healthy lifestyle.
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa,
08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.