A higher prednisolone dose results in a marked reduction in the relapse rate among patients with Takayasu arteritis (TA), reveals a recent study. Moreover, lower-dose prednisolone monotherapy appears to be a disadvantageous strategy for remission induction in TA despite low disease activity.
Evolocumab therapy demonstrates long-term efficacy, safety and tolerability in patients with homozygous (HoFH) and severe heterozygous familial hypercholesterolaemia (HeFH), reducing plasma low-density lipoprotein cholesterol (LDL-C) as well as the need for LDL apheresis, a study has shown.
Lim Jack Shen, assistant general manager of business development at Berjaya Corporation, talks about his experiences with developing MyTigas Alliance, a collaboration of independent community pharmacies for providing group healthcare services.
Use of virtual reality (VR) helps reduce pain during childbirth, and may present a novel nonpharmacologic approach to controlling labour pain, suggests a study presented at SMFM 2020 Annual Pregnancy Meeting in Grapevine, Texas, US.
Many children in Singapore may not be vaccinated according to the national recommended immunization schedule, with maternal age, ethnicity, household income, and number of siblings among the factors influencing non-adherence, according to findings from the GUSTO* study.
Ticagrelor plus acetylsalicylic acid (aspirin) demonstrates comparable antithrombotic potency to ticagrelor monotherapy in terms of ex vivo blood thrombogenicity among high-risk patients receiving drug-eluting stents, reveals a study. In contrast, markers sensitive to cyclo-oxygenase-1 blockade are higher in the absence of aspirin.
Administering daily oral doses of adjunctive perampanel is safe and well tolerated in the treatment of young and older children with focal seizures or generalized tonic‐clonic seizures, in addition to yielding about 40–70 percent reduction in seizure frequency, according to data from the open-label 311 Core Study.
Maintenance therapy with the anti-PD-L1* checkpoint inhibitor avelumab failed to show superior overall survival (OS) compared with continuation chemotherapy (CT) following first-line** (1L) CT in patients with previously untreated, unresectable, and locally advanced/metastatic HER2-negative gastric or gastroesophageal cancer (GC/GEJC), according to the results of the phase III JAVELIN Gastric 100 trial presented at ASCO GI 2020.
The combination of elagolix, an oral gonadotropin-releasing hormone (GnRH) antagonist, with hormonal add-back therapy significantly reduces heavy menstrual bleeding (HMB) in premenopausal women with uterine fibroids, according to two phase III studies.
The use of povidone iodine (PI) is more effective than chlorhexidine gluconate (CHG) at reducing vaginal bacterial colony counts in pregnancy and appears to be a superior vaginal antiseptic for decreasing postpartum infections, according to a study presented at the 2020 Annual Meeting of the Society for Maternal-Fetal Medicine (SMFM 2020).
Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng,
10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
A single infusion of the monoclonal antibody rituximab temporarily delays the clinical onset of rheumatoid arthritis (RA) through B-cell depletion, underpinning the preventive potential of rituximab in RA development especially in high-risk individuals, according to the PRAIRI* study.