Neoadjuvant chemotherapy with S-1 and oxaliplatin (SOX) may be a suitable treatment measure for patients with advanced gastric or esophagogastric junction adenocarcinoma, according to the RESONANCE* trial presented at ASCO GI 2020.
Isoniazid preventive therapy is safe to use in pregnant women with HIV, especially those with a CD4 count <350 cells/μl, conferring protection against incident tuberculosis (TB) without deleterious maternal and foetal consequences, a study has shown.
No significant difference is seen between entecavir and tenofovir disoproxil fumarate (TDF) in terms of their effectiveness for preventing hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB), according to a recent study.
Treatment with tenapanor 50 mg twice daily (bid) results in improvement of constipation-predominant irritable bowel syndrome (IBS-C) symptoms and is generally well tolerated, a phase III study has shown.
The combination of intravitreal aflibercept and antiplatelet-derived growth factor receptor β (anti-PDGFRβ) falls short of improving best-corrected visual acuity (BCVA) in patients with treatment-naïve neovascular age-related macular degeneration (nAMD), as compared with intravitreal aflibercept injection (IAI) monotherapy, a phase II study has shown.
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).
A US-based retrospective cohort study has shown no difference in the rates of mortality and cardiovascular disease (CVD) with initiation and continuous use of either analogue or human insulin in insulin-naïve adults with type 2 diabetes (T2D).
The use of apremilast in the treatment of patients with active ulcerative colitis (UC) falls short of inducing clinical remission, although it leads to marked improvements in clinical and endoscopic features and markers of inflammation, according to the results of a phase II trial.
The clinical and microbiological effectiveness of a single dose of oral fosfomycin trometamol is comparable to that of comparator antibiotics, as is safety, in women with confirmed or suspected acute uncomplicated cystitis, a recent study has shown. Use of fosfomycin trometamol is also associated with high patient compliance.
A 10-day or 14-day sequential therapy strategy is more cost-effective than a conventional triple therapy in the management of patients with Helicobacter pylori infection, in addition to being more effective in terms of eradication of infection, as reported in a study from Egypt.
Use of isatuximab (Isa) in combination with pomalidomide and dexamethasone (PomDex) appears to lead to more favourable outcomes in elderly patients with relapsed/refractory multiple myeloma (RRMM) as compared with PomDex alone, according to the results of a subgroup analysis of the ICARIA-MM trial presented at the 61st Annual Meeting of the American Society of Hematology (ASH 2019).
Pharmaceutical industry representatives highlighted lesser-known career opportunities for licensed pharmacists at the recent Pharmaceutical Industries Pharmacists Insights 3.0 (PIPI 3.0) symposium in Petaling Jaya.