Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.
Treatment with fruquintinib, an oral VEGFR* inhibitor, significantly improves overall survival (OS) among Chinese patients with metastatic colorectal cancer (CRC) in the third-line setting, according to the FRESCO** study.
Older individuals with osteoporosis who adopt a Mediterranean diet and take vitamin D supplements may experience significant improvements in femoral neck bone mineral density (BMD), according to the European-based NU-AGE* trial.
Treatment with denosumab in postmenopausal women with osteoporosis for 2 and/or 3, 5, and 10 years, compared with placebo, correlates with normal histology, low bone remodelling rate, increased matrix mineralization and lower mineralization heterogeneity, a recent study has shown. Such variables persist from years 5–10.
Statistically, augmented empirical prophylaxis (AEP) is superior to single agent empirical (SAEP) and targeted prophylaxis (TP), according to a large retrospective study. In some patients, sepsis has developed despite receiving a prophylactic antibiotic to which the sepsis-causing bacteria are sensitive.
Nonsteroidal anti-inflammatory drugs (NSAIDs) appear to increase the risk of major bleeding, stroke or systemic embolism, and hospitalization among patients with atrial fibrillation (AF), suggest the results of the RE-LY* trial. Moreover, there is no difference in the safety and efficacy of dabigatran etexilate (DE) 150 and 110 mg twice daily relative to warfarin.
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
In patients with moderate-to-severe chronic obstructive pulmonary disease (COPD), the drug combination of indacaterol/glycopyrronium (IND/GLY) is more cost-effective than the inhaled combination of salmeterol/fluticasone (SFC), a recent Singapore study has found.
Tigecycline is safe and effective in the treatment of necrotising skin and soft tissue infections due to resistant pathogens in critically ill and antimicrobially pre-treated patients, as reported in a prospective multi-centre non-interventional study.