Desmopressin (DDAVP) appears to be effective in reducing the rate of change in plasma sodium concentration, such that the proactive and reactive strategies of use result in safe correction of sodium levels in hyponatraemic patients at average risk of osmotic demyelination, a recent study has shown.
Treatment with beta-blockers does not appear to influence lung function, overall respiratory status and safety of tiotropium/olodaterol in patients with moderate to very severe chronic obstructive pulmonary disorder (COPD), according to data from the TONADO research programme.
Semaglutide appeared to render better reductions in HbA1c and weight compared with dulaglutide in individuals whose type 2 diabetes (T2D) was inadequately controlled on metformin, according to findings of the SUSTAIN 7* trial.
Administering intravitreal injections of ranibizumab in addition to panretinal photocoagulation (PRP) appears to be more effective than PRP monotherapy in terms of neovascularization regression in patients with high-risk proliferative diabetic retinopathy, according to a study.
A weekly dose escalation of regorafenib was superior to starting with the standard dose of 160 mg/day for patients with refractory metastatic colorectal cancer (mCRC), according to the ReDOS* trial presented at the ASCO GI Cancers Symposium 2018.
Ulipristal acetate appears to provide better control of bleeding compared with placebo, with more favourable rate of and time to amenorrhea, in women with symptomatic uterine leiomyomas, according to the results of a phase III study.
The androgen receptor inhibitor apalutamide prolonged metastasis-free survival (MFS) by approximately 2 years in men with nonmetastatic castration-resistant prostate cancer (nmCRPC) who are at high risk of metastatic disease, according to findings of the SPARTAN* trial.
Transdermal administration of emedastine difumarate provides effective control of symptoms of seasonal allergic rhinitis, with the effects sustained throughout the day and raising no safety signals of clinical concern, according to the results of a phase III trial.
Pearl Toh spoke with Dr Teh Ming Ming, senior consultant at the Department of Endocrinology, Singapore General Hospital (SGH), on the major challenges of diagnosing and managing diabetes in primary care, in conjunction with the World Diabetes Day on 14 November. Awareness of the symptoms of diabetes is important, and patients should be empowered to manage their conditions.
Empagliflozin appears to be beneficial to type 2 diabetes (T2D) patients with established cardiovascular disease (CVD) and chronic kidney disease (CKD), yielding reductions in CV and all-cause mortality, as well as in heart failure and all-cause hospitalization compared with placebo, according to a study.
Short-term treatment with methotrexate at >0.5 defined daily dose (8.75 mg/week) may help reduce the risk of ischaemic stroke in rheumatoid arthritis (RA) patients, while hydroxychloroquine and sulfasalazine have neutral effects, a retrospective study has found.