The adalimumab biosimilar BI 695501 shows similar efficacy and safety profile as its reference product in patients with moderate-to-severe Crohn's disease (CD), according to a phase III study recently presented at the Advances in Inflammatory Bowel Diseases (AIBD) 2019 Conference.
Despite the substantial disease burden from gout in Singapore — with a majority of the patients not being at the serum urate (SU) target, only two-thirds of the patients receive urate-lowering therapy (ULT), according to a local study.
New drug applications approved by US FDA as of 01 - 15 January 2020 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Patients with newly diagnosed multiple myeloma (MM) with suboptimal response to an immunomodulatory triplet regimen benefited from a response-adapted intensification regimen with cyclophosphamide, bortezomib, and dexamethasone (CVD), leading to improved depth of response (DpR) and progression-free survival (PFS), according to outcomes from the Myeloma XI trial.
Treating patients to intensive blood pressure (BP) targets poses an increased risk of impaired fasting glucose, with a small, nonsignificant elevation in the risk of developing diabetes mellitus, as shown in the results of a secondary analysis of SPRINT (Systolic Blood Pressure Intervention Trial).
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
The risk of acute kidney injury (AKI) appears to be lower among patients with type 2 diabetes mellitus receiving sodium-glucose cotransporter-2 inhibitors (SGLT2is), suggest the results of a systematic review and meta-analysis.
Use of lacosamide therapy in the long-term management of adult patients with epilepsy is effective and well tolerated, yielding seizure freedom rates comparable to that achieved with controlled‐release carbamazepine (carbamazepine‐CR), as reported in a recent study.
The addition of the oral phosphodiesterase-5 (PDE-5) inhibitor pentoxifylline to sildenafil failed to show benefit in men with erectile dysfunction (ED) with suboptimal response to sildenafil, a Singapore study shows.