An initial strategy of 1-year romosozumab followed by alendronate is superior over alendronate alone in reducing new vertebral fractures in postmenopausal women with osteoporosis at high risk for fracture, according to the ARCH* study.
Cyclosporine is as effective as infliximab in patients with steroid-refractory acute severe ulcerative colitis, having a similar colectomy rate but reduced incidence of serious adverse events, a study from Spain has shown.
Diclofenac reduces the use of antibiotics in women with uncomplicated lower urinary tract infection (UTI) but remains less effective than norfloxacin for symptom relief of UTI, according to a recent study. In addition, diclofenac appears to be associated with an elevated risk of pyelonephritis.
The launch of DCH Auriga marks the rebirth of LF Asia healthcare business. Starting November 2017, the healthcare business under LF Asia is rebranded to DCH Auriga Ltd., while the consumer goods distribution operations are transferred to Integrated Market Services Asia Ltd.
Use of the blood infection biomarker procalcitonin as a guide to prescribing antibiotics led to lower antibiotic exposure and side effects, as well as a lower mortality rate in individuals with acute respiratory infections, based on findings of a meta-analysis.
Ozanimod ─ a novel selective sphingosine 1-phosphate 1 (S1PR1) and 5 (S1PR5) receptor modulator ─ led to greater reduction in relapse rate and brain atrophy in patients with relapsing multiple sclerosis (MS) in a head-to-head comparison with the first-line treatment interferon β-1a (IFN), according to the SUNBEAM and RADIANCE trials presented at the ECTRIMS-ACTRIMS Meeting 2017 held in Paris, France.
Researchers from Japan have suggested several factors, namely younger age at DMARD* therapy initiation and low serum C-reactive protein (CRP) levels, as factors that may predict successful down-titration of biologic DMARDs in patients with rheumatoid arthritis.
Using bioabsorbable polymer drug-eluting stents (DES) with a shorter duration of double antiplatelet therapy (DAPT) in elderly patients undergoing percutaneous coronary intervention (PCI) leads to fewer adverse events than bare-metal stents (BMS) without increasing bleeding risk, according to the SENIOR* trial presented at TCT 2017 Congress.
Pearl Toh spoke with Dr Teh Ming Ming, senior consultant at the Department of Endocrinology, Singapore General Hospital (SGH), on the major challenges of diagnosing and managing diabetes in primary care, in conjunction with the World Diabetes Day on 14 November. Awareness of the symptoms of diabetes is important, and patients should be empowered to manage their conditions.
New drug applications approved by US FDA as of 1 - 15 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.