Ertugliflozin may be a suitable add-on therapy in patients with type 2 diabetes mellitus (T2DM) and established atherosclerotic cardiovascular disease (ASCVD) whose glucose levels are inadequately controlled by a metformin-sulfonylurea or insulin regimen, substudies of the phase III VERTIS* CV trial showed.
A 48-week course of combination therapy with pegylated interferon and tenofovir disoproxil fumarate appears to induce functional cure in patients with chronic hepatitis B, leading to a remarkable reduction in viral surface antigen levels (HBsAg) in the blood, according to real-world data.
Initiation of methotrexate appears to lower the risk of infection in patients with sarcoidosis at 6 months as compared to azathioprine, suggest the results from the emulation of a target trial with pre-existing data. However, the favourable effect of methotrexate is attenuated at 9 months.
Short-term use of either oral hydroxychloroquine (HCQ) and povidone-iodine throat spray have shown a signal of reducing the incidence of SARS-CoV-2 infection among young men living in a closed and high-exposure setting, with either compound being superior to oral vitamin C, as shown in an open-label trial from Singapore.
Higher dietary intake of the long-chain omega-3 fatty acids EPA and DHA* in childhood is associated with a reduced risk of developing asthma up till adolescence among children who harboured a common FADS** variant, according to data from the ALSPAC***.
Amidst the optimism from COVID-19 vaccine roll-out, the irrepressible yearning for normalcy is unmistakable. People are starting to drop their guard, thronging malls, and snapping up cruise tickets as soon as they become available.
High doses of zinc gluconate, ascorbic acid, or both do not shorten the duration of COVID-19 symptoms more than standard of care (SoC) in outpatients diagnosed with SARS-CoV-2, according to results of the prospective COVID A to Z trial.
Select stroke patients who present late to the hospital — beyond 6 hours and up to 24 hours after stroke onset — still stand to benefit from endovascular thrombectomy, confirms the AURORA meta-analysis of six randomized trials presented at the ISC 2021 Meeting.
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
The short-term use of alendronate prior to antiretroviral therapy (ART) initiation in people with HIV (PWH) helps prevent ART-associated bone mineral density (BMD) loss, according to the APART* study presented at CROI 2021.
The combination of sofosbuvir plus velpatasvir does as well in the real world as in a Japanese phase III trial in hepatitis C virus (HCV) patients with decompensated cirrhosis, although there have been incidences of treatment discontinuation and liver disease-related death, as reported by a team of researchers.
A 4-month regimen containing the combination of rifapentine (RPT) and moxifloxacin (MOX) can effectively treat tuberculosis (TB) in HIV-positive patients, performing just as well as the 6-month standard of care, according to a subgroup analysis of the landmark phase III S31/A5349 trial.