Desmopressin (DDAVP) appears to be effective in reducing the rate of change in plasma sodium concentration, such that the proactive and reactive strategies of use result in safe correction of sodium levels in hyponatraemic patients at average risk of osmotic demyelination, a recent study has shown.
Semaglutide appeared to render better reductions in HbA1c and weight compared with dulaglutide in individuals whose type 2 diabetes (T2D) was inadequately controlled on metformin, according to findings of the SUSTAIN 7* trial.
A weekly dose escalation of regorafenib was superior to starting with the standard dose of 160 mg/day for patients with refractory metastatic colorectal cancer (mCRC), according to the ReDOS* trial presented at the ASCO GI Cancers Symposium 2018.
Ulipristal acetate appears to provide better control of bleeding compared with placebo, with more favourable rate of and time to amenorrhea, in women with symptomatic uterine leiomyomas, according to the results of a phase III study.
The androgen receptor inhibitor apalutamide prolonged metastasis-free survival (MFS) by approximately 2 years in men with nonmetastatic castration-resistant prostate cancer (nmCRPC) who are at high risk of metastatic disease, according to findings of the SPARTAN* trial.
Transdermal administration of emedastine difumarate provides effective control of symptoms of seasonal allergic rhinitis, with the effects sustained throughout the day and raising no safety signals of clinical concern, according to the results of a phase III trial.
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.
The use of a ticagrelor/aspirin combination was more successful than a clopidogrel/aspirin combination in reducing the rate of high on-treatment platelet reactivity (HOPR) in patients with a recent minor stroke or transient ischaemic attack (TIA), according to results of the PRINCE* trial conducted in China.
Dr Michael Lim, consultant of the Division of Paediatric Pulmonary and Sleep in National University Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing paediatric asthma in the primary care setting.
Empagliflozin appears to be beneficial to type 2 diabetes (T2D) patients with established cardiovascular disease (CVD) and chronic kidney disease (CKD), yielding reductions in CV and all-cause mortality, as well as in heart failure and all-cause hospitalization compared with placebo, according to a study.
Short-term treatment with methotrexate at >0.5 defined daily dose (8.75 mg/week) may help reduce the risk of ischaemic stroke in rheumatoid arthritis (RA) patients, while hydroxychloroquine and sulfasalazine have neutral effects, a retrospective study has found.
Younger children appear to be more likely to experience behavioural side effects of antiepileptic drugs (AEDs), with the likelihood increasing if children with epilepsy have baseline hyperactivity/impulsivity, a retrospective study has found.