A 3-year sustained reduction of serum uric acid (SUA) with allopurinol was of no benefit to type 1 diabetes (T1D) patients with mild-to-moderate kidney disease, according to the PERL* study presented at the ASN 2019 Meeting.
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
Treatment with the SGLT2* inhibitor dapagliflozin appears to attenuate renal decline in patients with heart failure and reduced ejection fraction (HFrEF), regardless of whether they have CKD, according to a prespecified subanalysis of the landmark DAPA-HF trial presented at ASN Kidney Week 2019.
Combination therapy with empagliflozin plus linagliptin (E+L) reduces glomerular filtration rate (GFR), whereas metformin plus insulin glargine (M+I) confers benefits for both GFR and renal plasma flow (RPF) in type 2 diabetes mellitus (T2DM). The haemodynamic mechanism underlying these effects involves a decrease in efferent resistance with E+L and an increase in afferent resistance with M+I, according to the results of a randomized controlled trial presented at the American Society of Nephrology (ASN) Kidney Week 2019.
The administration of tranexamic acid within 3 hours of sustaining a traumatic brain injury (TBI) led to a reduction in mortality risk, highlighting the importance of early treatment in this setting, the CRASH*-3 trial has shown.
Roxadustat improves haemoglobin levels vs placebo and epoetin alfa, with similar safety profile, in 8,000 patients with chronic kidney disease (CKD)-related anaemia on- and off-dialysis, according to a pooled efficacy and CV safety analyses of roxadustat, spanning over 13,000 patient exposure years.
Treatment with sodium zirconium cyclosilicate in end-stage renal disease (ESRD) patients undergoing haemodialysis (HD) improves potassium balance and lessens the frequency of severe hyperkalaemia episodes, according to a posthoc analysis of the phase IIIB DIALIZE study.
Intensive urate lowering with the combination therapy of verinurad plus febuxostat is successful in lowering the urinary albumin to creatinine ratio (UACR) in patients with type 2 diabetes mellitus (T2DM), albuminuria and hyperuricaemia, according to a study presented at the American Society of Nephrology (ASN) Kidney Week 2019.
Treatment with cabazitaxel in patients with metastatic castration-resistant prostate cancer (mCRPC) results in a slightly lower median overall survival (OS) at 18 months as compared with that in the pivotal clinical trial, owing to the presence of features of poor prognosis at baseline and use of cabazitaxel in third line or beyond in 82 percent of patients, according to the FUJI study.
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.