Combination therapy with the NS5A inhibitor ledipasvir and NS5B inhibitor sofosbuvir appears to be highly effective in the management of chronic hepatitis C virus genotype 1 infection, yielding a sustained virologic response of >90 percent without increasing the incidence of serious adverse events, according to data from a real-world Japanese cohort.
Use of bevacizumab in combination with temozolomide yields no survival gains when compared with temozolomide alone in the treatment of patients with grade 2–3 glioma, according to the results of the open-label phase II TAVAREC trial.
The duration of action and long-term efficacy of dexamethasone implant in patients with persistent diabetic macular oedema (DMO) do not appear to be negatively affected by vitrectomy, a recent study has shown.
Rheumatoid arthritis remission may be sustained following abatacept tapering, particularly in patients with shorter disease duration and long sustained remission, according to a study. Furthermore, ultrasound is a useful tool to identify disease activity flare.
A 10-week treatment with a higher dose of hydrocortisone (HC) reduces tryptophan metabolism through the kynurenine pathway, according to a study. In addition, tryptophan metabolism mediates the effect of HC on fatigue and physical functioning in patients with secondary adrenal insufficiency (AI).
Acute coronary syndrome (ACS) patients with diabetes mellitus, as well as high-risk nondiabetic patients, appear to obtain significant cardioprotection from the addition of ezetimibe to simvastatin, and this benefit is achieved without compromising safety, according to an exploratory analysis of data from IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).
Taking long-chain omega-3 fatty acids (LC-OM3) supplements, mainly EPA* and DHA** omega-3s, was associated with a modest but significant reduction in cardiac death risk, according to a meta-analysis of randomized controlled trials (RCTs).
Copper intrauterine device exhibited superior efficacy to injectable progestin contraception in women attending termination of pregnancy services in South Africa, according to a pragmatic, open-label, parallel arm, randomised controlled trial.