Use of proton-pump inhibitor (PPI) significantly reduces the frequency and severity of dysphagia and improves the oesophageal peristaltic force in dysphagic patients with a pathologic acid exposure time (AET) and decreased peristaltic vigor, a recent study has shown.
Ranolazine has failed to significantly reduce the incidence of the first ventricular tachycardia (VT) or ventricular fibrillation (VF) or death in high-risk patients with implantable cardioverter-defibrillators (ICDs), a recent study has found. However, this study is underpowered to detect a difference in the primary endpoint.
Treatment with a neoadjuvant regimen containing fluorouracil, irinotecan and oxaliplatin (FOLFIRINOX) followed by individualized chemoradiotherapy for borderline resectable pancreatic cancer leads to high margin-negative resection rate, which translates to longer survival, according to the results of a single-arm phase II trial.
Ondansetron has been increasingly used for treating nausea and vomiting in pregnancy, and first-trimester exposure to the drug appears to pose no increased risk of birth defects, a study has found. However, there is a modest association found for cleft palate and renal agenesis–dysgenesis.
Treatment with pembrolizumab appears to produce durable objective response, with a favourable safety profile, in a subset of patients with heavily pretreated, advanced programmed cell death 1 ligand 1 (PD-L1)–positive prostate cancer, according to data from the KEYNOTE-028 trial.
The combination of trastuzumab and paclitaxel is well tolerated and results in objective tumour responses in nearly half (46 percent) of estimated glomerular filtration rate (EGFR) tyrosine kinase inhibitor (TKI)-pretreated patients with an activating EGFR mutation and HER2 expression, a recent study has found.
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.