Lubiprostone does not appear to have any favourable effect in the treatment of paediatric functional constipation (PFC), although the drug has a safety profile similar to that reported in adults, as shown in a phase III study.
Intravenous ketamine is well tolerated and demonstrates significant short-term efficacy in reducing depressive symptoms in adolescents with treatment-resistant depression as compared with an active placebo, according to a recent study.
Treatment with trastuzumab emtansine extends progression-free and overall survival with no serious safety concerns in patients with metastatic HER-2 positive breast cancer, reports a study. Eastern Cooperative Oncology Group-Performance Status (ECOG-PS), thrombocytopaenia, and cancer antigen 15-3 are all associated with survival.
Pharmacists play a significant role in identifying and correcting total parenteral nutrition dosing errors for both micro- and macronutrients at a specialized cancer care hospital, which leads to improvements in total parenteral nutrition-related complications and switches to enteral feeding, results of a study have shown.
Men with prostate cancer on active surveillance appear to fare well with 5-alpha-reductase inhibitors, which can help reduce both grade and volume progression without increasing the risk of developing high-grade tumours, a study has found.
While early-phase clinical trials may demonstrate substantial levels of overall response rates in patients with relapsed/refractory multiple myeloma (RRMM), high heterogeneity of evidence prevents the accurate assessment of clinical benefit before patient participation, reports a recent meta-analysis.
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Continuous infusion (CI) hydrocortisone therapy in patients with septic shock is not associated with a beneficial impact on mean blood glucose or influence glycaemic variability as compared to bolus dose (BD) therapy, reports a study.
Dupilumab effectively prevents severe asthma exacerbations and improves lung function in patients with difficult-to-treat type 2 asthma, according to a post hoc analysis of the LIBERTY ASTHMA QUEST study presented at AAAAI 2021.
Treatment with an intranasal budesonide aqueous spray led to significantly reduced nasal symptoms in adults with rhinitis exposed to high levels of airborne pollution, according to a study presented at AAAAI 2021.