There appears to be inconclusive evidence on the potential of the novel class of glucose-lowering drugs, namely sodium glucose-linked cotransporter 2 (SGLT2) inhibitors, in stroke therapy, according to the results of a systematic review. This is because few animal studies are available, and some of the clinical studies evaluate combinations of drug treatments of SGLT2 and other drugs related to diabetes treatment.
Treatment with tipifarnib appears to be safe with favourable efficacy in patients with treatment-refractory urothelial carcinoma harbouring HRAS mutations, according to the results of a phase II trial.
Patients with chronic pain and those with reported misuse of opioid medications exhibit reduced hedonic capacity compared with healthy individuals, suggesting that both chronic pain and opioid misuse have a hand in anhedonia, according to a study.
Use of pegylated interferon alpha 2a as an add-on therapy in chronic hepatitis B patients on tenofovir disoproxil fumarate facilitates rapid reductions in hepatitis B surface antigen (HBsAg) and core-related antigen (HBcrAg) levels, a study has shown.
Current use of antidepressants interfering selectively with the reuptake of serotonin and those antagonizing the 5‐HT2A receptor results in a reduced risk of acute myocardial infarction (AMI), a recent study has shown.
Using the standard American Urological Association (AUA) antibiotic prophylaxis for penile prosthesis surgery among diabetic men with erectile dysfunction results in significantly higher likelihood of postoperative device infection and device explantation compared with nonstandard prophylaxis, suggests a recent study.
Intraperitoneal therapy with paclitaxel and cisplatin does not result in longer progression-free or overall survival in the adjuvant setting among patients with stage III ovarian cancer as compared with dose-dense paclitaxel and carboplatin, results of a study have shown. In addition, tolerability appears to have decreased with intraperitoneal therapy.
In the treatment of cytokine storm syndrome due to the coronavirus disease (COVID-19), administering tocilizumab via the intravenous (IV) route appears to be more effective than subcutaneous (SC) therapy, leading to earlier symptom improvement and better survival, according to a study.
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.
The use of aspirin for primary prevention in patients without known cardiovascular diseases (CVDs) significantly reduces the risk of myocardial infarction (MI) but increases that of major bleeding and haemorrhagic stroke, according to a meta-analysis.