Use of pioglitazone is associated with a reduced risk of major adverse cardiovascular events (MACE) and is recommended in patients with or at high risk of type 2 diabetes (T2D), particularly those with a history of established cardiovascular disease (CVD), suggests a study.
Adjunctive treatment with low-dose intracoronary alteplase during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) and an ischaemic time ≥4 to 6 h results in increased microvascular obstruction (MVO), a study has shown. Intracoronary alteplase appears to be unsafe for this subgroup.
Neonatal BCG vaccination appears to reduce mortality both in tuberculosis (TB)-exposed and TB-unexposed children, according to a study, suggesting that timing of BCG administration factors in all-cause mortality.
In patients with Graves’ disease (GD), the block-replace antithyroid drug (ATD) regimen leads to a lower relapse rate than the titration regimen, according to a study. Factors such as younger age, larger goiter size or thyroid volume, and the higher free triiodothyronine or free thyroxine levels in the diagnosing phase are tied to a higher risk of relapse.
Perineal interferential current (IC) proves beneficial in the treatment of women with premature ovarian insufficiency (POI) who are using systemic hormone therapy (HT) and presenting with sexual complaints, with the results of a 4-week trial showing that IC yields favourable effects on pain, lubrication, satisfaction and orgasm as compared with topical estriol.
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Treatment with hydroxychloroquine appears to significantly reduce viral load in patients with the novel coronavirus disease (COVID-19), with its beneficial effects reinforced by adding azithromycin, results of a recent study have shown.
A blood pressure (BP) reading of 130/80 mm Hg or higher is the ‘new high’ in the latest AHA/ACC* hypertension guidelines, a threshold that is tighter than the JNC 7** cutpoint of 140/90 mm Hg for stage 1 hypertension in the general population. The change will mean more patients being labelled with hypertension.
The angiotensin receptor blocker (ARB) losartan did not improve inflammation, T-cell immune recovery, or fibrotic activity among older persons living with HIV (PLHIV) and viral suppression, according to data presented at CROI 2020.