Hydroxychloroquine (HCQ) inhibits the differentiation of Th17 cells and production of interleukin 17 (IL-17) both in vitro and in patients with systemic lupus erythematosus (SLE), a recent study has shown.
Use of amiodarone, beta-blockers or statins lowers the incidence of atrial fibrillation (AF) following noncardiac surgery, suggest the results of a meta-analysis. In addition, statins and amiodarone have a relatively low overall risk of short-term adverse events.
The risk of cardiovascular (CV) events is lower in psoriasis patients treated with tumour necrosis factor-alpha inhibitors (TNFi) than in those treated with phototherapy, according to a recent US study.
Rates of thromboembolism and valve thrombosis are higher in patients receiving dual antiplatelet therapy (DAPT; aspirin 325 mg and clopidogrel 75 mg) vs controls in the low-risk arm, according to the results of the Prospective Randomized On-X Anticoagulation Trial (PROACT).
Use of opioid pain medication among adults with comorbid symptoms of insomnia and chronic pain appears to prolong time spent being awake in bed, reports a study, adding that such effect cannot be attributed to changes in pain, use of sleep medication or total sleep time.
Among preterm infants without culture-confirmed sepsis, exposure to antibiotics in the first week of life is not independently associated with an elevated risk of bronchopulmonary dysplasia (BPD) or death, according to a study.
Adding bavituximab to docetaxel in the treatment of patients with previously treated advanced nonsmall cell lung cancer (NSCLC) does not provide survival advantage, although the combination appears to be well tolerated, according to the results of a phase III study.
Prof. Cheuk-Chun Szeto, Dr. Winston W. S. Fung,
25 Jan 2018
A 65-year-old lady with a background of type 2 diabetes, hyperlipidaemia and chronic immune thrombocytopenia presented to us with a 2-week history of generalized malaise and myalgia. Shortly after the onset of myalgia, she was noted to have reduced urine output and the urine was described as dark in colour. Her regular medications included prednisolone, danazol, simvastatin, metformin, and human insulin. Upon further questioning, the patient admitted that her compliance to simvastatin and danazol used to be poor. However, she recently started to take both medications regularly after repeated education.
Use of statins may not be neuroprotective, in contrast to findings from previous observational studies. On the contrary, fungus-derived or lipophilic statins appeared to be associated with a slightly increased risk of Alzheimer's disease (AD) compared with synthetic and hydrophilic statins, suggests a new study based on real-world clinical practice data.
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.