Patients with advanced idiopathic pulmonary fibrosis (IPF) at the time of initiation with nintedanib or pirfenidone demonstrate more stable lung function over time, but substantially higher risk of death, compared to those with mild-to-moderate IPF, according to the results of a recent study.
Bempedoic acid may be a boon to patients with full statin intolerance, as its addition can lessen the need for proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and serve as a less expensive alternative to established oral lipid-lowering medications, according to a study.
New pharmacological and nonpharmacological management strategies should be implemented for people with severe hypertension, suggest the results of a study involving a large primary prevention population in France.
Use of tofacitinib for rheumatoid arthritis (RA) may lead to reactivation of hepatitis B virus (HBV), especially among hepatitis B surface antigen-positive (HBsAg+) and HBsAg-negative/hepatitis B core antibody-positive (HBsAg–/HBcAb+) patients, according to a study from Taiwan.
Treatment with tocilizumab, an interleukin (IL)-6 receptor antagonist, is effective for corticosteroid sparing in patients with giant cell arteritis (GCA), suggests a study. However, tocilizumab allows for a prolonged remission in fewer than half of the patients following treatment discontinuation.
Dual therapy with immune checkpoint inhibitors does not appear to prolong overall survival as compared with sunitinib alone for advanced renal cell carcinoma patients with favourable risk, according to the results of a meta-analysis.
The risk of developing advanced colorectal neoplasia in patients with chronic kidney disease (CKD) is strongly associated with older age, male sex, and exposure to erythropoiesis-stimulating agents and azathioprine, a study has found.
Among patients with ST-segment–elevation myocardial infarction, treatment with high-dose colchicine at the time of reperfusion does not minimize myocardial damage induced by ischemia-reperfusion and the resulting inflammation, a study has shown.