Treatment with mineralocorticoid antagonists (MRAs) appears to be useful in lowering blood pressure (BP) in already treated hypertensive patients who did not reach target BP values, according to the results of a meta-analysis.
In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.
Antiandrogens, insulin sensitizers and oestrogen-progestin oral contraceptive pills (OCPs) are all effective in the treatment of hirsutism, suggest the results of a systematic review and meta-analysis.
Ofatumumab appears to be effective and well-tolerated in the treatment of patients with long-standing systemic lupus erythematosus, offering an alternative to the B cell–depleting agent rituximab, according to a study.
Compared to other tumour necrosis factor–α inhibitors (TNFi), infliximab remains superior in reducing Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) at 12 weeks, results of a network meta-analysis (NMA) have shown. However, it was sensitive to inclusion of an open-label trial, and its efficacy faded at 24 weeks.
Access to primary care has increased and hospital and emergency department (ED) utilization has decreased with the adoption of a multidisciplinary outpatient-based transitions programme embedded in the patient-centred medical home (PCMH), reports a study. Additionally, face-to-face clinical pharmacist practitioner involvement has significantly reduced rehospitalizations.
Antidepressants may be effective for treating depression in patients with schizophrenia, according to a meta-analysis that underscores qualifying conclusions based on the small number of low- or moderate-quality studies.
Antiviral treatment for colonic cytomegalovirus (CMV) infection significantly improves short- and long-term surgery-free survival in patients with ulcerative colitis (UC), according to the results of a small-scale study.
The sulfonylurea glimepiride may pose an increased risk of hypoglycaemia in a subgroup of elderly type 2 diabetes (T2D) patients with lower β-cell function when added to a metformin regimen, according to a post-hoc analysis of data from the GENERATION* trial.
Once-monthly and once-quarterly administration of paliperidone palmitate had similar efficacy in terms of relapse prevention for schizophrenia in an East Asian population, according to a subgroup analysis.