Twelve weeks of treatment with ledipasvir plus sofosbuvir may yield a sustained virologic response (SVR) of 100 percent in a group of patients coinfected with hepatitis C (HCV) and hepatitis B (HBV) viruses, as reported in a recent study. Most patients may have an increase in HBV DNA level that is not associated with signs or symptoms.
Intraperitoneal chemotherapy is well tolerated in women with stage IIIC or IVA epithelial ovarian cancer (EOC) treated with neoadjuvant chemotherapy and optimal debulking surgery, as well as improves progressive disease rate compared with chemotherapy administered intravenously, according to the results of a phase II study.
Intraprostatic injections of 2-hydroxyflutamide depot formulations are safe and well tolerated and confer antitumour benefits in men with localized prostate cancer, a recent study has shown. In addition, higher doses and better dose distribution are recommended for better anticancer effects.
Tirofiban does not appear to contribute to an increased risk of symptomatic intracerebral haemorrhage in patients with acute ischaemic stroke undergoing endovascular thrombectomy, but rather confers benefits for survival and long-term functional independence, a study has found.
The use of oral antidepressants appears to have beneficial effects on patients with chronic pruritus not responding to topical treatment and oral antihistamines, particularly those with uremic pruritus, cholestatic pruritus or paraneoplastic pruritus, according to a recent study.
The incidence of cardiovascular events in the first year following a primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) is comparable between patients given prasugrel and ticagrelor post-surgery, according to results of the PRAGUE-18* trial presented at AHA 2017.
The presence of vitreous haze, snow banking, and choroidal involvement is associated with an increased risk of antitubercular treatment failure in patients with tubercular (TB) uveitis, according to research by the COTS-1* Study Group.