Clinical Review

An increased risk of overdose events in the next 24 weeks is seen in patients with opioid use disorder seeking medication treatment who fail to initiate or discontinue medication and those who report using benzodiazepine at baseline, reports a study.

Treatment with topical cidofovir leads to faster clearance of skin lesions in patients with monkeypox but mild systemic involvement, according to a study. Time to resolution reduction can shorten isolation time and enhance the cosmetic impact in areas such as the face.

Empiric azithromycin appears to have no substantial impact on shock duration, mechanical ventilation duration, intensive care unit (ICU) length of stay (LOS), hospital LOS, or in-hospital mortality in septic shock patients admitted to the ICU, according to a study.

For individuals with increased projected risk of probable dementia or amnestic mild cognitive impairment (MCI) who are prescribed antihypertensive treatment, intensive systolic blood pressure (SBP) lowering confers greater cognitive benefits than standard treatment, according to a secondary analysis of the SPRINT trial.

Treatment with clevidipine in patients undergoing cardiac surgery leads to better perioperative blood pressure (BP) control relative to nicardipine, with a slight rise in cost and no significant difference in safety outcomes, a study has found.

Adding glucagon-like peptide-1 receptor agonists (GLP1RA) onto metformin, sulfonylurea, or insulin treatment alone or in combination appears to reduce the incidence of major adverse cardiac events (MACE) and heart failure (HF) hospitalization relative to treatment with dipeptidyl peptidase-4 inhibitors (DPP4i), suggests a study.

Use of amiodarone in older patients with atrial fibrillation (AF) who are being treated with apixaban or rivaroxaban results in a higher risk of bleeding-related hospitalizations compared with the use of flecainide or sotalol, reports a study.

A 3-year course of weekly oral vitamin D supplementation, while safe and effective at increasing serum 25(OH)D concentrations, does little to reduce the risk of contracting tuberculosis (TB) infection in children, as shown in the results of a phase III study.

Treatment with brepocitinib at 30 and 60 mg daily outperforms placebo at relieving signs and symptoms of psoriatic arthritis (PsA), with a safety profile consistent with that seen in other brepocitinib trials, according to data from a phase IIb study.

Supplementation with fish oil during pregnancy of mothers with overweight or obesity does not appear to have a significant impact on the body composition of infants, reveals a recent study.