Treatment with dupilumab appears to lower incidence of skin infections and eczema herpeticum in adults with moderate-to-severe atopic dermatitis (AD), according to a recent study, adding that the mechanism underlying this association is likely related to improvement in AD severity.
Twelve weeks of treatment with ledipasvir plus sofosbuvir may yield a sustained virologic response (SVR) of 100 percent in a group of patients coinfected with hepatitis C (HCV) and hepatitis B (HBV) viruses, as reported in a recent study. Most patients may have an increase in HBV DNA level that is not associated with signs or symptoms.
Intraperitoneal chemotherapy is well tolerated in women with stage IIIC or IVA epithelial ovarian cancer (EOC) treated with neoadjuvant chemotherapy and optimal debulking surgery, as well as improves progressive disease rate compared with chemotherapy administered intravenously, according to the results of a phase II study.
Intraprostatic injections of 2-hydroxyflutamide depot formulations are safe and well tolerated and confer antitumour benefits in men with localized prostate cancer, a recent study has shown. In addition, higher doses and better dose distribution are recommended for better anticancer effects.
Tirofiban does not appear to contribute to an increased risk of symptomatic intracerebral haemorrhage in patients with acute ischaemic stroke undergoing endovascular thrombectomy, but rather confers benefits for survival and long-term functional independence, a study has found.
The use of oral antidepressants appears to have beneficial effects on patients with chronic pruritus not responding to topical treatment and oral antihistamines, particularly those with uremic pruritus, cholestatic pruritus or paraneoplastic pruritus, according to a recent study.
Pregnant women do not need to suffer unnecessary pain or potentially dangerous fever for fear of their taking medications that may be harmful to their unborn baby. Healthcare providers should be confident when prescribing appropriate treatment to such women during pregnancy.
Most women presenting with complications in early pregnancy are assessed, diagnosed and managed at early pregnancy assessment units (EPAUs). These units aim to provide thorough assessments, access to specialist investigations (scan, human chorionic gonadotrophin [hCG]), a rapid turnaround of results, and co-ordination of further management.