High dose thoracic radiotherapy (RT) does not impact lung volume significantly. However, membrane and capillary alteration decreased lung diffusion with full recovery observed in 6 months, according to findings from the French CONORT* study.
A subanalysis of Asian women in the global phase III PALOMA-3* trail showed that a palbociclib/fulvestrant combination overcame endocrine resistance in this population of breast cancer patients as effectively as in the whole study cohort and could be a reasonable therapeutic option, the researchers said.
Immunotherapy with pembrolizumab, an anti-PD-L1 antibody, improved survival in pre-treated advanced non-small-cell lung cancer (NSCLC) patients who were PD-L1 positive compared to docetaxel, according to results from the phase II/III KEYNOTE-010* trial presented at the inaugural European Society for Medical Oncology (ESMO) Asia 2015 Congress held recently in Singapore.
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Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.