The phase IIIb PONENTE trial* aims to assess if adults with severe eosinophilic asthma who are treated with benralizumab can safely reduce their doses of oral corticosteroid (OCS) therapy, while still maintaining asthma control.
The anti-interleukin-5 receptor alpha monoclonal antibody benralizumab significantly reduced the rates of severe exacerbations (SevEx) and asthma worsening episodes (AWE) in patients with severe asthma, leading to a reduction in the risk of overall CompEx* events, according to a post hoc analysis of the phase III SIROCCO** and CALIMA*** trials presented at ATS 2019.
Using budesonide/formoterol as needed was as effective as budesonide maintenance therapy in preventing exacerbations but with a lower exposure to ICS among patients with mild asthma, including adolescent patients and regardless of prior treatment used, according to two subgroup analyses of the SYGMA* 1 and 2 studies presented at the ATS 2019 Congress.
Influenza vaccination effectively reduced the risk of influenza-related hospitalizations in patients with chronic obstructive pulmonary disease (COPD) compared with those who were not vaccinated, according to a study presented at ATS 2019.
Use of isatuximab (Isa) in combination with pomalidomide and dexamethasone (PomDex) appears to lead to more favourable outcomes in elderly patients with relapsed/refractory multiple myeloma (RRMM) as compared with PomDex alone, according to the results of a subgroup analysis of the ICARIA-MM trial presented at the 61st Annual Meeting of the American Society of Hematology (ASH 2019).
New drug applications approved by US FDA as of 16 - 30 November 2018
which includes New Molecular Entities (NMEs) and new biologics. It does
not include Tentative Approvals. Supplemental approvals may have
occurred since the original approval date.
Use of regional anaesthesia-analgesia using paravertebral blocks and the anaesthetic propofol does not lead to a lower risk of breast cancer recurrence after potentially curative surgery as compared with general anaesthesia with the volatile anaesthetic sevoflurane and opioid analgesia, according to a study.