Three studies presented at the American Society of Hematology (ASH) 58th Annual Meeting held in San Diego, California, US highlight the use of chimeric antigen receptor (CAR) T cell therapy for the treatment of refractory adult and paediatric lymphoma and leukaemia.
Findings from a phase III trial show that the anti-CD30 antibody-drug conjugate, brentuximab vedotin (BV), is superior to methotrexate or bexarotene in the efficacy endpoint of overall response rate (ORR) lasting ≥4 months in the treatment of cutaneous T cell lymphoma (CTCL).
Cancer patients who have undergone successful treatment may have increased risk of developing therapy-related myeloid neoplasms (t-MNs), a fatal form of secondary malignancy, even after years of successful treatment, according to a recent study presented at the ASH 58th Annual Meeting in San Diego, California, US.
Lenalidomide maintenance therapy reduces the risk of progression by more than 80 percent in patients with high-risk chronic lymphocytic leukaemia (CLL) who responded to first-line chemoimmunotherapy, interim results of the phase III CLL M1 study have shown.
Obinutuzumab reduces the risk of disease progression by about one-third in patients with advanced follicular lymphoma (FL) compared with rituximab, interim results of the phase III GALLIUM study have shown.
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Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
The addition of pertuzumab to a trastuzumab-docetaxel regimen in the neoadjuvant setting improved total pathological complete response (tpCR) rates in Asian women with early or locally advanced ERBB2-positive breast cancer, according to the phase III PEONY trial from China.
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.