Two phase II trials of once-daily concizumab injections for bleeding prophylaxis do not disappoint, with the drug shown to be both safe and effective in haemophilia A (HA) and haemophilia A/B with inhibitors (HAwI/HBwI).
The bi-specific T-cell engaging antibody blinatumomab bested chemotherapy as a post-reinduction consolidation prior to transplant in children and adolescents and young adults (AYAs) with first-relapse B-cell acute lymphoblastic leukaemia (B-ALL), according to phase III data presented at ASH 2019, highlighting the potential of blinatumomab as a new standard of care in this setting.
Acalabrutinib, when combined with obinutuzumab or used as monotherapy, significantly improves progression-free survival (PFS) by 80–90 percent vs chemoimmunotherapy in patients with previously-untreated chronic lymphocytic leukaemia (CLL), results of the phase III ELEVATE TN trial have shown.
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.