Inhibition of the Notch signaling pathway by DAPT prevents proliferation and migration of ductus arteriosus smooth muscle cells (DASMCs) following induction by angiotensin-II (Ang-II), a new study presented at the recently concluded 21st Asian Pacific Society of Cardiology Congress (APSC 2017) has shown.
The use of sodium-glucose co-transporter 2 (SGLT2) inhibitors such as empagliflozin and canagliflozin may lead to a decreased risk of heart failure (HF), according to data presented at the Asian Pacific Society of Cardiology Congress (APSC) 2017 held in Singapore.
East Asians with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) have lower incidence of thrombotic events but higher risk of bleeding compared with their Western counterparts in response to antiplatelet therapy, necessitating the need for guidance on antiplatelet treatment strategies specific for East Asian patients.
Alirocumab has a positive effect on low-density lipoprotein cholesterol (LDL-C) levels and appears to be well tolerated in patients with hypercholesterolemia and high cardiovascular risk, according to a sub-analysis of Taiwanese patients enrolled in the ODYSSEY KT* clinical trial.
There is significant heterogeneity among Asian patients with heart failure, with patients from Southeast Asia appearing to have the highest risk factor burden, according to findings of the ASIAN-HF* registry study presented at the 21st Asian Pacific Society of Cardiology Congress (APSC 2017) held in Singapore.
Transcatheter aortic valve replacement (TAVR) is the standard of care for high-risk patients with severe aortic stenosis (AS), and may be superior to open surgery in patients with lower risk as newer generation devices emerge, according to a presentation at the APSC Congress 2017 in Singapore.
Increasing the dose of loop diuretic at hospital discharge of patients with heart failure (HF) was not associated with a reduced risk of hospital readmission for HF or any cause contrary to previous reports suggesting that such a dosing strategy could reduce readmission, according to a study presented at the 21st Asian Pacific Society of Cardiology Congress (APSC 2017) in Singapore.
Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.
Treatment with rituximab (RTX) is well tolerated and leads to stability or improvement in pulmonary function or severity of interstitial lung disease (ILD) on computed tomography (CT) in most patients, a recent study has shown.
The dual-action antibody directed against epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3), duligotuzumab, does not appear to provide survival advantage compared with cetuximab in patients with RAS exon 2/3 wild-type metastatic colorectal cancer treated with the FOLFIRI regimen, according to the results of a phase II trial.
The sulfonylurea glimepiride may pose an increased risk of hypoglycaemia in a subgroup of elderly type 2 diabetes (T2D) patients with lower β-cell function when added to a metformin regimen, according to a post-hoc analysis of data from the GENERATION* trial.