Pharmacy

Top Medical News
Pearl Toh, Yesterday
Using regional citrate for anticoagulation during dialysis significantly extends the lifespan of dialysis filter compared with systemic heparin anticoagulation, although this has no impact on the patients’ mortality rate over 1 year, according to the RICH study presented at ASN 2020.
Yesterday
Treatment with the long-acting injectable antipsychotic aripiprazole appears to reduce hospitalization in recent-onset schizophrenia, which can lead to a lower socioeconomic healthcare burden, according to a study.
Yesterday
Treatment with rituximab (RTX) results in better 2-year progression-free survival (PFS) compared to cyclophosphamide (CYC) despite similar PFS at 6 months in patients with antisynthetase syndrome (AS)-related interstitial lung disease (ILD), a study has shown.
Yesterday
Women exposed to hormonal therapy are at risk of developing noninfectious uveitis, although the risk increase is modest, according to a study.
Roshini Claire Anthony, 2 days ago

The efficacy of lanifibranor in reducing histological markers of non-alcoholic steatohepatitis (NASH) is comparable in patients with and without type 2 diabetes (T2D), according to the phase IIb NATIVE study presented as a poster at AASLD 2020.

2 days ago
Atrial fibrillation patients receiving direct oral anticoagulants may be at risk of gastrointestinal (GI) bleeding, a recent study has found. This must be taken into consideration when prescribing anticoagulants, particularly to elderly patients.
2 days ago
Prasugrel appears to do better than ticagrelor in attenuating the combined 1-year risk of death, myocardial infarction (MI), and stroke without increasing bleeding risk in patients with non-ST-segment elevation (NSTE) acute coronary syndrome (ACS), a recent study has shown.
Special Reports
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Roshini Claire Anthony, 05 Nov 2020

Adding empagliflozin to recommended therapy in patients with heart failure with reduced ejection fraction (HFrEF) reduced the risk of HF hospitalization and slowed renal function decline, the EMPEROR-Reduced* trial showed.

26 Oct 2020

An estimated 463 million adults – about one in 11 – had diabetes in 2019. These numbers are expected to rise to 700 million by 2045. Worse, one in two people are undiagnosed. [https://www.idf.org/, accessed 19 October 2020]

Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Conference Reports
Pearl Toh, 28 Nov 2020
Using regional citrate for anticoagulation during dialysis significantly extends the lifespan of dialysis filter compared with systemic heparin anticoagulation, although this has no impact on the patients’ mortality rate over 1 year, according to the RICH study presented at ASN 2020.
Roshini Claire Anthony, 27 Nov 2020

The efficacy of lanifibranor in reducing histological markers of non-alcoholic steatohepatitis (NASH) is comparable in patients with and without type 2 diabetes (T2D), according to the phase IIb NATIVE study presented as a poster at AASLD 2020.

Audrey Abella, 27 Nov 2020
Use of the potent and selective PPARδ* agonist seladelpar led to improvements in histologic responses and liver chemistry in patients with biopsy-confirmed nonalcoholic steatohepatitis (NASH), a phase II study has shown.
Roshini Claire Anthony, 25 Nov 2020

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

Audrey Abella, 25 Nov 2020
Reductions in liver fat and adipose tissue volumes were sustained in patients with type 2 diabetes (T2D) with the addition of the SGLT-2* inhibitor dapagliflozin (DAPA) and the DPP-4** inhibitor saxagliptin (SAXA) to metformin (MET), compared with a regimen comprising glimepiride (GLIM)+MET, according to the extension period results of a phase IIIb trial.
Pearl Toh, 24 Nov 2020
A topical gel treatment derived from birch bark significantly speeds up wound healing compared with standard care in patients with epidermolysis bullosa (EB) lesions, according to the EASE trial presented at the EADV 2020 Conference — representing the first-ever treatment to show positive results for the rare skin disorder.
Elaine Soliven, 24 Nov 2020
Treatment with apremilast led to significantly improved patient-reported quality of life (QoL) outcomes in patients with moderate-to-severe plaque psoriasis of the scalp, according to the STYLE* study presented at EADV 2020.
CME Modules
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