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Real-world study stamps seal of safety on dabigatran

Pearl Toh, an hour ago

Real-world studies on patients with atrial fibrillation (AF) show that dabigatran is safe with low bleeding and stroke rates when used for long term (over 2 years) or used continuously in patients undergoing cardiovascular (CV) interventions, according to phase II results of the prospective, observational, global registry programme GLORIA-AF* presented at the EHRA 2018 Annual Congress.

Statins protect against limb loss, death in peripheral artery disease

Jairia Dela Cruz, 2 hours ago

Statins, especially high-intensity formulations, show therapeutic potential in peripheral artery disease, according to a study. Specifically, using the drug upon diagnosis results in a significant reduction in the risk of limb loss and mortality as compared with nonuse or treatment with antiplatelet medications only.

Fewer women respond to TNFi therapy for ankylosing spondylitis

Yesterday

There are fewer women who respond to tumour necrosis factor inhibitors (TNFi) among patients with ankylosing spondylitis (AS), a recent study has shown. Additionally, women show reduced treatment response compared to men.

Mitochondrial-targeted antioxidants improve vascular function in elderly adults

Tristan Manalac, Yesterday

Therapies targeted at mitochondrial reactive oxygen species (ROS) appear to be effective against age-related vascular dysfunction, according to a recent study, which reports that MitoQ, a mitochondrial-targeted antioxidant, improves vascular endothelial function in elderly adults.

No benefit to targeted antibiotic prophylaxis before TRUS-guided prostate biopsy

Roshini Claire Anthony, Yesterday

Targeted antibiotic prophylaxis – after a rectal swab to identify specific intestinal flora – does not appear to significantly impact the risk of urinary sepsis following a transrectal ultrasound (TRUS)-guided prostate biopsy, according to a recent study.

Excerpts from Journey to Pain-Free Living Starts with You – CPD workshop for pharmacists

01 Mar 2018

Lifetime prevalence of acute pain leading to the use of analgesics approaches 100% in the general population, and pharmacists are a pivotal first point of contact for patients in their journey to better pain management. Noting the need for pharmacists to be more aware of their evolving role as a community pharmacist, GlaxoSmithKline Consumer Healthcare partnered with MIMS Education to organize a workshop that served as a platform for robust knowledge-sharing. Below are highlights from the workshop.

Antihistamine therapy for allergic rhinitis and urticaria: An Asia-Pacific perspective

27 Dec 2017

The prevalence of allergic diseases in the Asia-Pacific region is expected to rise over the next 20 years, driven by rapid economic development and urbanization. Allergic diseases have high socioeconomic impact by impairing productivity and quality of life, and the impact may be greater in Asia-Pacific than in Europe due to the presence and predominance of perennial allergens.

Cochrane review confirms Atopiclair efficacy in eczema

22 Dec 2017

Eczema (atopic dermatitis) is a chronic inflammatory skin disease that can present in many different forms. However, it is principally characterized by dry skin, intense itching, and the presence of inflammatory skin lesions. [J Eur Acad Dermatol Venereol 2016;30:604-618; N Engl J Med 2008;358:1483-1494; Lancet 2016;387:1109-1122]

New Science on Probiotics: International Meeting of Probiotics & Personalized Medicine 2017 (IMPPM 2017)

01 Nov 2017

Since the beginning of the probiotic era in the 20th century, much emphasis has been given on its role in the regulation of gut health. The past decades have seen increasing evidence on the benefits of probiotics beyond just gut health, to even encompass, skin health, memory and brain health, and immunity.

Optimizing medical treatment for symptomatic angina: What’s new, what’s hot?

Dr. Yeo Khung Keong, Dr. Wiwun Tungsubutra, Prof. Peter Collins, 31 Aug 2017

Agents such as beta-blockers and calcium antagonists have been the cornerstone of treatment for stable angina for some time. However, new options are emerging for patients who remain inadequately controlled on conventional therapies. At a recent Menarini-sponsored symposium held during the APSC Congress 2017 in Singapore, three experts discussed the current treatment landscape, as well as changing paradigms and new effective options for patients with symptomatic angina.

No benefit to targeted antibiotic prophylaxis before TRUS-guided prostate biopsy

Roshini Claire Anthony, 23 Apr 2018

Synthetic androgen shows promise as male birth control pill

Pearl Toh, 20 Apr 2018

The investigational oral synthetic androgen dimethandrolone undecanoate (DMAU) suppresses serum testosterone levels to near castrate levels and appears safe when taken once daily for a month, showing potential as a male contraceptive pill, according to a study.

New ESC syncope guidelines stratify patients who may be discharged from the ED safely

Elvira Manzano, 18 Apr 2018

An algorithm to help stratify patients with syncope requiring hospitalization vs those that can be discharged from the emergency department (ED) safely forms part of the new European Society Cardiology (ESC) syncope guidelines launched at the EHRA 2018 meeting.

Semaglutide confers significant weight loss in obese, nondiabetic patients

Roshini Claire Anthony, 18 Apr 2018

Individuals with obesity but without diabetes experienced significant weight reduction with daily doses of the glucagon-like peptide-1 receptor agonist semaglutide, according to a recent study presented at ENDO 2018.

Continuous apixaban may be safe alternative to warfarin during AF ablation

Pearl Toh, 17 Apr 2018

Continuous apixaban seems equally safe as warfarin and other vitamin K antagonists (VKAs) during atrial fibrillation (AF) ablation in patients at risk for stroke, according to the AXAFA–AFNET* 5 trial presented at EHRA 2018.

Closed-loop insulin pump may improve glycaemic outcomes in children with T1D

Roshini Claire Anthony, 16 Apr 2018

The use of a hybrid closed-loop insulin pump, which has shown promise in improving glycaemic outcomes in adolescents and adults with type 1 diabetes, may also be beneficial in children, according to a study presented at ENDO 2018.

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