Pharmacy

Top Medical News
P-gp/CYP3A4 inhibitor use ups bleeding, mortality risks in NOAC-treated AF patients
7 hours ago
Bleeding and mortality risks are elevated in atrial fibrillation (AF) patients treated with nonvitamin K antagonist oral anticoagulant (NOAC) who are also using P-glycoprotein (P-gp) and CYP3A4 inhibitors, reports a study, noting the need for close monitoring of these individuals.
Type 3c diabetes is caused by injury to the pancreas, and is often misdiagnosed as type 2 diabetes.
Yesterday
The novel neoadjuvant therapy S-1, an oral fluoropyrimidine agent containing tegafur, gimeracil, and oteracil potassium, yields promising survival outcomes in high-risk patients with resectable pancreatic ductal adenocarcinoma, a recent study has found.
Tirzepatide: A winning weight-loss therapy for nondiabetic, obese adults
Roshini Claire Anthony, Yesterday

Non-diabetic overweight or obese adults experienced a greater reduction in weight and cardiometabolic measures with the addition of tirzepatide to their lifestyle interventions, findings of the SURMOUNT-1 trial showed.

Long-term PPI tied to pneumonia in older adults
Yesterday
Treatment with proton pump inhibitors (PPI) appears to increase the risk of mortality among patients with advanced nonsmall cell lung cancer (NSCLC) undergoing systemic antitumour therapy, reveals a recent study.
Tranexamic acid does not prevent haemorrhage-related events in Caesarean section
Yesterday

Among women with multiple pregnancies, prophylactic treatment with tranexamic acid does not appear to reduce the incidence of blood loss-related events following caesarean delivery, a study has shown.

Dabigatran continues to be safe, useful in NVAF patients during idarucizumab era
2 days ago
Even after the dabigatran-specific reversal agent idarucizumab has been made available, dabigatran continues to be safe and well-tolerated for stroke and systemic embolism prevention in patients with nonvalvular atrial fibrillation (NVAF), reports a recent Japan study.
Maintenance niraparib a boon in advanced ovarian cancer
Jairia Dela Cruz, 2 days ago

Use of niraparib in the maintenance setting appears to minimize the risk of progression in advanced ovarian cancer patients, with surgical timing having little to no effect on the drug’s efficacy, as shown in a post hoc analysis of the phase III PRIMA/ENGOT-OV26/GOG-3012 study.

Special Reports
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15 Jun 2022
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Empagliflozin: A new dawn for heart failure treatment across the ejection fraction spectrum
06 Jun 2022

Initially approved to improve glycaemic control and reduce cardiovascular death in adults with type 2 diabetes (T2D), the SGLT-2* inhibitor empagliflozin reduced hospitalization for heart failure (HFH) or cardiovascular death and delayed renal function decline when added to recommended therapy in patients with heart failure and reduced ejection fraction (HFrEF) in the EMPEROR-Reduced** trial. The EMPEROR-Preserved** trial has now shown that the benefits of empagliflozin extend to patients with heart failure and preserved ejection fraction (HFpEF).

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Conference Reports
Tirzepatide: A winning weight-loss therapy for nondiabetic, obese adults
Roshini Claire Anthony, 25 Jun 2022

Non-diabetic overweight or obese adults experienced a greater reduction in weight and cardiometabolic measures with the addition of tirzepatide to their lifestyle interventions, findings of the SURMOUNT-1 trial showed.

Baricitinib delays, lowers frequency of flares in JIA
Roshini Claire Anthony, 23 Jun 2022

In patients with juvenile idiopathic arthritis (JIA) with insufficient response to conventional synthetic (cs) or biologic (b) disease-modifying antirheumatic drugs (DMARDs), the JAK*1/2 selective inhibitor baricitinib reduced the frequency and delayed time to disease flares, according to a phase III trial presented at EULAR 2022.

Dostarlimab in rectal cancer: are we inching towards a cure?
Audrey Abella, 22 Jun 2022
In what has been dubbed as ‘a small but mighty study’ at ASCO 2022, a phase II trial spearheaded by investigators from Memorial Sloan Kettering Cancer Center in New York, US heralded the remarkable efficacy and safety of the monoclonal antibody dostarlimab for the treatment of locally advanced mismatch repair-deficient (dMMR) rectal cancer.

Semaglutide reduces long-term T2D risk in overweight/obese patients
Elaine Soliven, 21 Jun 2022
Once-weekly injection of semaglutide significantly reduced the 10-year risk of developing type 2 diabetes (T2D) among overweight or obese patients, according to a post hoc analysis of the STEP* 1 and 4 trials presented at ADA 2022.
Bimekizumab triumphs in bDMARD-naïve psoriatic arthritis patients
Roshini Claire Anthony, 20 Jun 2022

Patients with psoriatic arthritis (PsA) with no prior exposure to biological disease-modifying antirheumatic drugs (bDMARDs) experience improvements in their condition when treated with bimekizumab, according to results of the phase III BE OPTIMAL trial.

Dulaglutide: A new horizon for T2D treatment in kids
Roshini Claire Anthony, 18 Jun 2022

A once-weekly subcutaneous dose of the GLP-1* receptor agonist dulaglutide successfully controlled glycaemic levels in youths with type 2 diabetes (T2D) being treated with lifestyle modification with or without metformin or insulin, results of the multinational, phase III AWARD-PEDS** study showed.

Bimekizumab shows promise across the spectrum of axial spondyloarthritis
Elaine Soliven, 18 Jun 2022
Treatment with bimekizumab, a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F and IL-17A, significantly improved ASAS40* response rate in patients with either nonradiographic axial spondyloarthritis (nr-axSpA) or ankylosing spondylitis (AS**), according to two phase III studies presented at EULAR 2022.
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