peptic%20ulcer%20disease
PEPTIC ULCER DISEASE
Peptic ulcer disease is the presence of ulceration in the stomach and proximal duodenum commonly and in the lower esophagus, distal duodenum or jejunum infrequently. It is characterized by mucosal damage secondary to pepsin and gastric acid secretion.
It is the principal cause of upper gastrointestinal hemorrhage.
Appropriate therapy depends on the cause of peptic ulcer disease.

Peptic Ulcer Disease References

  1. ASGE Standards of Practice Committee, Banerjee S, Cash BD, Dominitz JA, et al. The role of endoscopy in the management of patients with peptic ulcer disease. Gastrointest Endosc. 2010 Apr;71(4):663-668. PMID: 20363407
  2. Lanza FL, Chan FK, Quigley EM; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol. 2009 Mar;104(3):728-738. doi: 10.1038/ajg.2009.115. Accessed 15 Jul 2011. PMID: 19240698
  3. Laine L, Jensen DM. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012 Mar;107(3):345-360. doi: 10.1038/ajg.2011.480. PMID: 22310222
  4. Ramakrishnan K, Salinas RC. Peptic ulcer disease. Am Fam Physician. 2007 Oct;76(7):1005-1012. Accessed 15 Jul 2011. PMID: 17956071
  5. Napolitano L. Refractory peptic ulcer disease. Gastroenterol Clin North Am. 2009 Jun;38(2):267-288. doi: 10.1016/j.gtc.2009.03.011. PMID: 19446258
  6. Truter I. Evidence-based pharmacy practice (EBPP): peptic ulcer disease. SA Pharmaceutical Journal. 2009 Jan;76(1):010-20
  7. MedWormhttp://www.medworm.com/rss/index.php/Gastroenterology/17/http://www.medworm.com/rss/medicalfeeds/specialities/Gastroenterology.xml
  8. Ministry of Health (Malaysia), Malaysian Society of Gastroenterology and Hepatology, Academy of Medicine (Malaysia). Clinical practice guidelines: management of non-variceal upper gastrointestinal bleeding. http://www.acadmed.org.my. Apr 2003.
  9. Mayo Clinic staff. Peptic Ulcer. http://www.mayoclinic.com. Jan 2011. Accessed 10 Jul 2013.
  10. Anand BS. Peptic ulcer disease. http://emedicine.medscape.com. Jun 2012. Accessed 10 Jul 2013.
  11. National Institute for Health and Care Excellence. Management of dyspepsia in adults in primary care. NICE. http://www.nice.org.uk. Aug 2004. Accessed 15 Jul 2011.
  12. Cohen S. Peptic ulcer disease. http://www.merckmanuals.com. Feb 2012. Accessed 10 Jul 2013.
  13. Sollano JD, Daez MLO, Dee GA, et al. Philippine consensus statements on the management of non-variceal upper gastrointestinal bleeding: 2012. Philippine Journal of Internal Medicine. 2012 Jul-Sep;50(3):1-13. http://www.pcp.org.ph. Accessed 20 Nov 2013
  14. Fashner J, Gitu A. Diagnosis and treatment of peptic ulcer disease and H. pylori infection. Am Fam Physician. 2015 Feb;91(4):236-242. PMID: 25955624
  15. Gralnek IM, Dumonceau JM, Kuipers EJ, et al. Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy. 2015 Oct;47(10):a1-a46. doi: 10.1055/s-0034-1393172. PMID: 26417980
  16. Siau K, Chapman W, Sharma N, et al. Management of acute upper gastrointestinal bleeding: an update for the general physician. J R Coll Physicians Edinb. 2017 Sep;47(3):218-230. doi: 10.4997/JRCPE.2017.303. PMID: 29465096
  17. Vakil NB. Peptic ulcer disease: clinical manifestations and diagnosis. UpToDate. https://www.uptodate.com. 14 Jan 2020. Accessed 20 Nov 2018.
  18. Vakil NB. Peptic ulcer disease: epidemiology, etiology, and pathogenesis. UpToDate. https://www.uptodate.com. 02 Mar 2020. Accessed 28 Sep 2020.
  19. Vakil NB. Peptic ulcer disease: management. UpToDate. http://www.uptodate.com. 05 Sep 2017.
  20. Wolfe MM. Proton pump inhibitors: overview of use and adverse effects in the treatment of acid related disorders. UpToDate. http://www.uptodate.com. 29 Nov 2017.
  21. Barkun AN, Almadi M, Kuipers EJ, et al. Management of nonvariceal upper gastrointestinal bleeding: guideline recommendations from the International Consensus Group. Ann Intern Med. 2019 Dec;171(11):805-822. doi: 10.7326/M19-1795. Accessed 29 Sep 2020. PMID: 31634917
  22. Kavitt RT, Lipowska AM, Anyane-Yeboa A, et. al. Diagnosis and treatment of peptic ulcer disease. Am J Med. 2019 Apr;132(4):447-456. doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
  23. Kuna L, Jakab J, Smolic R, et al. Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options. J Clin Med. 2019 Feb;8(2):179. doi: 10.3390/jcm8020179. PMID: 30717467
  24. National Institute for Health and Care Excellence (NICE). Gastro-esophageal reflux disease and dyspepsia in adults: investigation and management. NICE. https://www.nice.org.uk/. 21 Oct 2019. Accessed 28 Sep 2020.
  25. Tarasconi A, Coccolini F, Biffl WL, et al. Perforated and bleeding peptic ulcers: WSES guidelines. World J Emerg Surg. 2020 Jan;15:3. doi: 10.1186/s13017-019-0283-9. PMID: 31921329
  26. Vakil NB. Antiulcer medications: mechanism of action, pharmacology, and side effects. UpToDate. https://www.uptodate.com. 13 Apr 2020.
  27. Vakil NB. Peptic ulcer disease: treatment and secondary prevention. UpToDate. https://www.uptodate.com. 01 Apr 2020.
  28. Vernon AH, Ferzoco SJ, Ashley SW. Surgical management of peptic ulcer disease. UpToDate. https://www.uptodate.com. 07 Oct 2019. Accessed 28 Sep 2020.
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