Penile cancer is a rare type of malignant growth that occurs on the skin or tissues of the penis.

It often presents as a palpable visible penile lesion w/ signs that may include pain, bleeding, discharge or a foul odor.

The lesion may be fungating, nodular or ulcerative and may be concealed by phimosis.

Differential Diagnosis

  • There are several differential diagnoses that need to be ruled out & these include infectious, inflammatory, premalignant & malignant etiologies:
    • Infectious: Genital herpes, primary syphilis
    • Inflammatory: Angiokeratomas, genital psoriasis, lichen planus
    • Premalignant: Condyloma acuminata, cutaneous horn, leukoplakia, lichen sclerosis or balanitis xerotica obliterans, pseudoepitheliomatous keratotic & micaceous balanitis (PKMB)
    • Malignant: Basal cell carcinoma, Kaposi sarcoma, malignant melanoma, urethral carcinoma, metastasis from another primary tumor site
  • Refer patient for further investigation & appropriate treatment
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