Parkinson's disease is a progressive neurodegenerative disorder that is common, age-related and chronic.
It is caused by loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain.
Onset of symptoms and progression of the disease is gradual.
Motor signs and symptoms include resting tremor, rigidity, bradykinesia and postural instability.
Parkinson's disease dementia indicates loss of intellectual functions
including memory, significant deterioration in the ability to carry out
day-to-day activities and changes in social behavior are often noted.
New drug applications approved by US FDA as of 16 - 31 August 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Individuals living within 50 metres of high-voltage overhead power lines tend to have heightened risk of Alzheimer’s dementia or Parkinson’s disease compared with those residing at >600 metres, suggesting that exposure to extremely low-frequency magnetic fields may contribute to an increase in the risk of these neurodegenerative diseases, a study reports.
Levodopa-induced complications can lead to significant worsening of quality of life (QoL) in Asian patients with Parkinson’s disease (PD), necessitating that clinicians monitor their patients closely and promptly manage such complications, according to a longitudinal local study.
Concussion is associated with a substantial long-term risk of dementia in older adults, but the risk can be reduced modestly with the use of statins, a large population-based double cohort study has shown.
Use of the antihypertensive drug isradipine did not reduce the progression of Parkinson’s disease, according to the STEADY-PD III* study presented at the American Academy of Neurology annual meeting (AAN 2019).
Twenty-four–hour treatment with levodopa-carbidopa intestinal gel appears to result in a substantial reduction in troublesome dyskinesia duration in patients with Parkinson’s disease, a study has shown.
Older men who experience long napping durations and excessive daytime sleepiness (EDS) have greater odds of developing Parkinson’s disease, a study suggests. This is not true for older men who report only EDS.
Prompt treatment with tranexamic acid may reduce intracerebral haemorrhage (ICH) growth in patients with ongoing bleeding, though the timing of treatment appears to be key to improved outcomes, according to a study presented at ISC 2020.