Parkinson's disease is a progressive neurodegenerative disorder that is common, age-related and chronic.
It is caused by loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain.
Onset of symptoms and progression of the disease is gradual.
Motor signs and symptoms include resting tremor, rigidity, bradykinesia and postural instability.
Parkinson's disease dementia indicates loss of intellectual functions
including memory, significant deterioration in the ability to carry out
day-to-day activities and changes in social behavior are often noted.
Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.