pancreatitis%20-%20chronic
PANCREATITIS - CHRONIC
Chronic pancreatitis develops from irreversible scarring sustained by the pancreas from prolonged inflammation.
Signs and symptoms include abdominal pain that is epigastric in location that radiates to the back and frequently occurs at night or after meals, symptoms of fat, protein & carbohydrates maldigestion that become apparent with advanced chronic pancreatitis and presence of diarrhea.
Chronic pancreatitis results in destruction of alpha and beta cells which gives rise to deficiencies of both insulin and glucagon.
  1. Warshaw AL, Banks PA, Fernández-Del Castillo C. AGA technical review: treatment of pain in chronic pancreatitis. Gastroenterology. 1998 Sep;115(3):765-776. PMID: 9721175
  2. American Gastroenterological Association. American Gastroenterological Association medical position statement: treatment of pain in chronic pancreatitis. Gastroenterology. 1998 Sep;115(3):763-764. PMID: 9721174
  3. Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis classification, and new genetic developments. Gastroenterology. 2001 Feb;120(3):682-707. PMID: 11179244
  4. Feldman M, Friedman LS, Sleisenger MH, eds. Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology/diagnosis/management. 7th ed. Pennsylvania: Saunders; 2002
  5. MedWormhttp://www.medworm.com/rss/index.php/Gastroenterology/17/http://www.medworm.com/rss/medicalfeeds/specialities/Gastroenterology.xml
  6. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  7. The Society for Surgery of the Alimentary Tract. SSAT patient care guidelines: operative treatment for chronic pancreatitis. http://www.ssat.com. May 2004. Accessed 15 Aug 2005.
  8. Banks PA, Conwell DL, Toskes PP. The management of acute and chronic pancreatitis. Gastroenterol Hepatol (NY). 2010 Feb;6(2 Suppl 3):1-16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886461/pdf/GH-06-S5-1.pdf. Accessed 05 Mar 2014. PMID: 20567557
  9. Freedman SD. Treatment of chronic pancreatitis. UpToDate. http://www.uptodate.com. 08 Oct 2013. Accessed 05 Mar 2014.
  10. Forsmark CE. Pancreatitis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016. 963-967. :963-967.
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
18 Sep 2019
Mortality, length of stay (LOS) and hospital charges are significantly higher in chronic liver disease (CLD) patients with fractures, a recent study has shown. These findings are also associated with increased infection, bleeding and poorer wound healing.
01 Aug 2017
New drug applications approved by US FDA as of 16 - 30 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 04 Oct 2017

Using a reduced computed tomography (CT) dose to diagnose appendicitis in adolescents and young adults does not appear to affect clinical outcomes, and could potentially reduce the long-term risk of radiation-related cancers, according to results of the LOCAT* trial. 

22 Sep 2019
Oral supplementation with the gut commensal bacterium Akkermansia muciniphila safely improves several metabolic parameters in overweight or obese adults, as shown in a proof-of-concept study.