Diffuse panbronchiolitis is an inflammatory disease affecting the respiratory bronchioles.
It causes progressive suppurative and obstructive respiratory disease.
This is an idiopathic disease which is primarily found in Japan, Korea and China.
Predisposition to the disease may be genetically-related but environmental factors should also be considered.
Failure to treat diffuse panbronchiolitis can lead to development of bronchiectasis, progressive failure and death.

Surgical Intervention

Invasive Exam

  • Eg bronchoscopy w/ lavage, surgical lung biopsy
  • Done to confirm the diagnosis if findings of the radiographic studies are non-specific
  • Bronchiolar inflammation w/ transmural infiltrates of lymphocytes, plasma cells, & foam cells are seen in lung biopsy
  • Fluid obtained via bronchoscopy often reveals increased lymphocytes & neutrophils
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