Panbronchiolitis%20-%20diffuse Signs and Symptoms
Introduction
- This is an idiopathic disease which is primarily found in Japan, Korea & China
- Predisposition to the disease may be genetically-related but environmental factors should also be considered
- Failure to treat diffuse panbronchiolitis (DPB) leads to development of widespread bronchiectasis, progressive respiratory failure & death
Epidemiology
- More common in 2nd-5th decade of life
- Not related to smoking & exposure to toxic fumes
- High incidence in Asian countries (Japan, Korea, Taiwan, Malaysia, China, Thailand, Singapore)
Definition
- Inflammatory disease affecting the respiratory bronchioles
- Causes progressive suppurative & obstructive respiratory disease
Signs and Symptoms
- Chronic paranasal sinusitis (>80%)
- Productive cough which usually occurs in the 2nd-5th decade of life
- Wheezing
- Dyspnea on exertion