panbronchiolitis%20-%20diffuse
PANBRONCHIOLITIS - DIFFUSE
Diffuse panbronchiolitis is an inflammatory disease affecting the respiratory bronchioles.
It causes progressive suppurative and obstructive respiratory disease.
This is an idiopathic disease which is primarily found in Japan, Korea and China.
Predisposition to the disease may be genetically-related but environmental factors should also be considered.
Failure to treat diffuse panbronchiolitis can lead to development of bronchiectasis, progressive failure and death.

Introduction

  • This is an idiopathic disease which is primarily found in Japan, Korea & China
  • Predisposition to the disease may be genetically-related but environmental factors should also be considered
  • Failure to treat diffuse panbronchiolitis (DPB) leads to development of widespread bronchiectasis, progressive respiratory failure & death

Epidemiology

  • More common in 2nd-5th decade of life
  • Not related to smoking & exposure to toxic fumes
  • High incidence in Asian countries (Japan, Korea, Taiwan, Malaysia, China, Thailand, Singapore)

Definition

  • Inflammatory disease affecting the respiratory bronchioles
  • Causes progressive suppurative & obstructive respiratory disease

Signs and Symptoms

  • Chronic paranasal sinusitis (>80%)
  • Productive cough which usually occurs in the 2nd-5th decade of life
  • Wheezing
  • Dyspnea on exertion
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Respirology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 3 days ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 5 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
Jairia Dela Cruz, 3 days ago
A treatment regimen combining daratumumab plus bortezomib, melphalan and prednisone markedly extends progression-free survival in patients with multiple myeloma, inducing deep responses and demonstrating acceptable tolerability regardless of baseline renal function, according to the results of the phase III ALCYONE study.
Yesterday
Segmentectomy and lobectomy confer similar overall survival (OS) and lung cancer-specific survival (LCSS) among patients with primary nonsmall cell lung cancer (NSCLC) of ≤20 mm without lymph node or distant metastasis, a recent study has shown.