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PANBRONCHIOLITIS - DIFFUSE
Diffuse panbronchiolitis is an inflammatory disease affecting the respiratory bronchioles.
It causes progressive suppurative and obstructive respiratory disease.
This is an idiopathic disease which is primarily found in Japan, Korea and China.
Predisposition to the disease may be genetically-related but environmental factors should also be considered.
Failure to treat diffuse panbronchiolitis can lead to development of bronchiectasis, progressive failure and death.

Introduction

  • This is an idiopathic disease which is primarily found in Japan, Korea & China
  • Predisposition to the disease may be genetically-related but environmental factors should also be considered
  • Failure to treat diffuse panbronchiolitis (DPB) leads to development of widespread bronchiectasis, progressive respiratory failure & death

Epidemiology

  • More common in 2nd-5th decade of life
  • Not related to smoking & exposure to toxic fumes
  • High incidence in Asian countries (Japan, Korea, Taiwan, Malaysia, China, Thailand, Singapore)

Definition

  • Inflammatory disease affecting the respiratory bronchioles
  • Causes progressive suppurative & obstructive respiratory disease

Signs and Symptoms

  • Chronic paranasal sinusitis (>80%)
  • Productive cough which usually occurs in the 2nd-5th decade of life
  • Wheezing
  • Dyspnea on exertion
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