Treatment Guideline Chart
Diffuse panbronchiolitis is an inflammatory disease affecting the respiratory bronchioles.
It causes progressive suppurative and obstructive respiratory disease.
This is an idiopathic disease which is primarily found in Japan, Korea and China.
Predisposition to the disease may be genetically-related but environmental factors should also be considered.
Failure to treat diffuse panbronchiolitis can lead to development of bronchiectasis, progressive failure and death.

Panbronchiolitis - Diffuse References

  1. Brown KK. Chronic cough due to nonbronchiectatic suppurative airway disease (bronchiolitis): ACCP evidence-based clinical practice guidelines. Chest. 2006 Jan;129(1):132S-137S. http://chestjournal.chestpubs. org/. Accessed 16 Jul 2010. PMID: 16428702
  2. Anthony MP, Singham S, Soans B. Diffuse panbronchiolitis: not just an Asian disease: Australian case series and review of the literature. Biomed Imaging Interv J. 2009 Oct;5(4):e19. doi: 10.2349/biij.5.4.e19. Accessed 20 Jul 2010
  3. Nath A, Aggarwal AN, Gupta R. Diffuse panbronchiolitis: report of a rare disease from India. Indian J Chest Dis Allied Sci. 2009;52:43-45. Accessed 20 Jul 2010
  4. Schultz MJ. Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis. J Antimicrob Chemother. 2004 Jul;54(1):21-28. PMID: 15190022
  5. Poletti V, Casoni G, Chilosi M, et al. Diffuse panbronchiolitis. Eur Respir J. 2006 Oct;28(4):862-871. PMID: 17012632
  6. Azuma A, Kudoh S. The use of macrolides for treatment of diffuse panbronchiolitis. In: Rubin BK, Tamaoki J, eds. Antibiotics as antiinflammatory and immuno-modulatory agents. Basel, Switzerland: Birkhauser Verlag; 2005. Accessed 20 Jul 2010:147-162
  7. MedWorm
  8. King TE. Diffuse panbronchiolitis. UpToDate. May 2014. Accessed 28 Jul 2014.
  9. Kono C, Yamaguchi T, Yamada Y, et al. Historical changes in epidemiology of diffuse panbronchiolitis. Sarcoidosis Vasc Diffuse Lung Dis. 2012 Mar;29(1):19-25. Accessed 28 Jul 2014. PMID: 23311119
  10. Azuma A, Kudoh S. Diffuse panbronchiolitis in East Asia. Respirology. 2006;11(3):249-261. Accessed 26 Aug 2014. PMID: 16635082
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