paget's%20bone%20disease
PAGET'S BONE DISEASE
Paget's bone disease, also known as osteitis deformans, is characterized by a significant increase in bone resorption and turnover in localized parts of the skeleton causing enlargement and thickening of the bone that is disordered and architecturally unstable.
The prevalence increases with age, with men and women affected equally.
Genetic factors and/or viral infection may play a role in the etiology.
May affect one bone (monostotic) or several bones (polyostotic).
By decreasing frequency, involved bones may include pelvic bone and sacrum, spine, skull and femur, tibia, humeri and clavicles.

Definition

  • Paget’s bone disease, also known as osteitis deformans, is characterized by a significant increase in bone resorption & turnover in localized parts of the skeleton causing enlargement & thickening of the bone that is disordered & architecturally unstable

Signs and Symptoms

Signs & Symptoms

  • Asymptomatic for a long period of time before signs & symptoms occur
  • Bone or joint pain
  • Bone enlargement or bone deformity (eg skull enlargement, bowing of long bones)
    • Pelvis & tibia are one of the most commonly affected bones

Risk Factors

  • Prevalence increases w/ age, w/ men & women affected equally
  • Genetic factors &/or viral infection may play a role in the etiology
  • May affect one bone (monostotic) or several bones (polyostotic)
  • By decreasing frequency, involved bones may include pelvic bone & sacrum, spine, skull & femur, tibia, humeri & clavicles
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