paget's%20bone%20disease
PAGET'S BONE DISEASE
Paget's bone disease, also known as osteitis deformans, is characterized by a significant increase in bone resorption and turnover in localized parts of the skeleton causing enlargement and thickening of the bone that is disordered and architecturally unstable.
The prevalence increases with age, with men and women affected equally.
Genetic factors and/or viral infection may play a role in the etiology.
May affect one bone (monostotic) or several bones (polyostotic).
By decreasing frequency, involved bones may include pelvic bone and sacrum, spine, skull and femur, tibia, humeri and clavicles.

Paget's Bone Disease References

  1. Deftos LJ. Treatment of Paget's disease-taming the wild osteoclast. N Engl J Med. 2005 Sep;353(9):872-875. http://www.nejm.org/doi/pdf/10.1056/NEJMp058184. PMID: 16135831
  2. Delmas PD, Meunier PJ. The management of Paget's disease of bone. N Engl J Med. 1997 Feb;336(8):558-566. http://www.nejm.org/doi/pdf/10.1056/NEJM199702203360807. PMID: 9023094
  3. Rousière M, Michou L, Cornélis F, Orcel P. Paget's disease of bone. Best Pract Res Clin Rheumato. 2003 Dec;17(6):1019-1041. PMID: 15123049
  4. Schneider D, Hofmann MT, Peterson JA. Diagnosis and treatment of Paget's disease of bone. Am Fam Physician. 2002 May;65(10):2069-2072. PMID: 12046775
  5. Selby PL. Guidelines for the diagnosis and management of Paget's disease: a UK perspective. J Bone Miner Res. 2006 Dec;21(Suppl 2):P92-P93. PMID: 17229017
  6. Selby PL, Davie MWJ, Ralston SH, et al; Bone and Tooth Society of Great Britain; National Association for the Relief of Paget's Disease. Guidelines on the management of Paget's disease of bone. Bone. 2003 Sep;31(3):366-373. PMID: 12231408
  7. Whyte MP. Clinical practice. Paget's disease of bone. N Engl J Med. 2006 Aug;355(6):593-600. http://www.nejm.org/doi/full/10.1056/NEJMcp060278. PMID: 16899779
  8. Altman, Roy D. Paget's disease of bone. Merck Manual; 2007 Dec. http://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/paget-disease-of-bone/paget-disease-of-bone. Accessed 27 Jun 2011.
  9. Klemm KM, Klein MJ. Biochemical markers of bone metabolism. In: McPherson RA, Pincus MR, eds. Henry's clinical diagnosis and management by laboratory methods. 21st. Philadelphia, PA: Saunders, Elsevier; 2006.
  10. Ferri FF. Paget's disease of the bone. In: Alvero R, Borkan JM, Dobbs MR, et al, eds. Ferri’s clinical advisor. 1st ed. Philadelphia: Mosby Inc, an affiliate of Elsevier; 2012
  11. Rosenberg AE. Bones, joints, and soft-tissue tumors. In: Kumar V, Abbas AK, Fausto N, et al. Robbins and Cotran pathologic basis of disease. 8th ed. Philadelphia, PA: Saunders, Elsevier; 2010.
  12. Raisz LG, Kream BE, Lorenzo JA. Metabolic bone disease. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. William's Textbook of Endocrinology. 10th ed. Philadelphia: Saunders, an imprint of Elsevier; 2003
  13. MedWormhttp://www.medworm.com/rss/index.php/Endocrinology/15/http://www.medworm.com/rss/medicalfeeds/specialities/Endocrinology.xml
  14. Kelepouris N. Clinical manifestation and diagnosis of Paget's disease of bone. UpToDate. http://www.uptodate.com/index. Sep 2009. Accessed 03 Jul 2011.
  15. The Paget Foundation for Paget’s disease of bone and other related disorders. A physician’s guide to the management of Paget's disease of bone. http://www.paget.org/index.php/healthcare-professionals/pagets-disease-of-bone/126-a-physicians-guide-to-the-management-of-pagets-disease-of-bone.html. Accessed 27 Jun 2011
  16. Kline MJ, Chew FS. Paget's disease. http://www.emedicine.medscape.com/article/394165-overview#a20. May 2011. Accessed 27 Jun 2011
  17. Singer F. Paget's disease of bone. Endotext.com. http://www.endotext.org/parathyroid15/parathyroid15.htm
  18. American Academy of Orthopedic Surgeons. Paget's disease of bone [fact sheet]. http://orthoinfo.aaos.org/topic.cfm?topic=A00076. Aug 2001
  19. Seton M. Treatment of Paget's disease of bone. UpToDate. http://www.uptodate.com/index. Oct 2009. Accessed 03 Jul 2011
  20. The Paget Foundation for Paget’s disease of bone and other related disorders. The management of Paget's disease of the bone. http://www.paget.org/Information/FactSheet/mgmt_of_ pdisbone.Html. Dec 2001
  21. Murphy J, Altman R; American College of Rheumatology Communications and Marketing Committee. Paget’s disease of bone. American College of Rheumatology website. http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Pagets-Disease-of-Bone. Apr 2015.
  22. Ralston SH. Clinical practice. Paget’s disease of bone. N Engl J Med. 2013 Feb;368(7):644-650. http://www.nejm.org/doi/pdf/10.1056/NEJMcp1204713. PMID: 23406029
  23. Singer FR, Bone HG 3rd, Hosking DJ, et al; Endocrine Society. Paget’s disease of bone: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014 Dec;99(12):4408-4422. http://press.endocrine.org/doi/pdf/10.1210/jc.2014-2910. PMID: 25406796
  24. Charles JF. Clinical manifestations and diagnosis of Paget disease of bone. UpToDate. http://www.uptodate.com. Feb 2018.
  25. Charles JF. Treatment of Paget disease of bone. UpToDate. http://www.uptodate.com. Feb 2019.
  26. Ralston SH, Corral-Gudino L, Cooper C, et al. Diagnosis and management of Paget’s disease of bone in adults: a clinical guideline. J Bone Miner Res. 2019 Apr;34(4):579-604. doi: 10.1002/jbmr.3657. PMID: 30803205
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