Treatment with voxelotor, an HbS* polymerization inhibitor, significantly increases haemoglobin (Hb) levels and reduces markers of haemolysis, including indirect bilirubin level and percentage of reticulocytes, compared with placebo in patients with sickle cell disease, according to the HOPE** trial.
Exposure to acid suppression therapy, such as proton pump inhibitors, within the first year of life appears to pose an increased fracture risk in children, with the risk amplified by days of use and earlier initiation, a study has found.
Children with noncritical infections and no gastrointestinal symptoms show similar gut and innate immune cell alterations as those with severe sepsis or organ failure, according to a study. Such changes are associated with increased morbidity and mortality and with a higher risk of future infections.
Teens with severe obesity need not wait until they are adults to undergo Roux-en-Y gastric bypass, with 5-year follow-up data from a recent study showing that the bariatric procedure leads to substantial weight loss that is similar in magnitude in adolescents and adults.
A 2-week course of the immunotherapy drug teplizumab delayed the onset of type 1 diabetes (T1D) in individuals at high risk for the condition, according to a phase II trial conducted by the TrialNet Study Group and presented at ADA 2019.
In children with newly diagnosed type 1 diabetes (T1D), earlier initiation of devices, such as an insulin pump or a continuous glucose monitor, improves glycaemic control within the first year of diagnosis, according to a recent study.
Patients with youth-onset type 2 diabetes (T2D) are more likely to have an increased rate of cardiovascular (CV), kidney, eye, nerve, and pregnancy complications as they transition to early adulthood, according to the longest-running TODAY*2 study presented at ADA 2019.
Continuous glucose monitors (CGMs) are valuable tools for controlling type 1 diabetes among children and young adults, as well as for improving patient satisfaction with diabetes care, according to two studies presented in a joint symposium at the recently concluded 79th Scientific Sessions of the American Diabetes Association at the Moscone Convention Center in San Francisco.
Children with early-onset type 1 diabetes (T1D) and poor glycaemic control have a slower growth of brain regions associated with sensory processing and cognition compared with nondiabetic controls, according to a longitudinal study of brain growth by the DirecNet*.
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.