Shortening the 10-day course of intravenous antibiotic therapy by at least 2 days in the management of infants with uncomplicated, late-onset group B streptococcus (GBS) bacteraemia appears to be effective with low rates of disease recurrence and treatment failure, according to a study.
New drug applications approved by US FDA as of 16 - 31 October 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Infants fed formula milk gain weight at a more rapid rate compared with those fed breast milk, according to data from the CHILD* birth cohort. The favourable effect of breast milk on anthropometric outcomes is dose dependent but slightly attenuated when babies are fed via a bottle than when nursed directly.
Young people who do not identify with heterosexuality tend to exhibit significantly greater suicidal and life-threatening behaviours than their heterosexual counterparts, according to a recent meta-analysis.
Treatment with canakinumab yields a rapid, substantial improvement in disease activity in children with systemic juvenile idiopathic arthritis (sJIA), according to long-term extension data from two phase III pivotal trials. Furthermore, response is sustained for up to 5 years, allowing dose reduction or even discontinuation of glucocorticoids without raising new safety concerns.
Use of triple antiretroviral therapy (ART) during pregnancy and breastfeeding did not affect the cognitive development and function of the offspring compared with those whose mothers were not exposed to ART, reveals the IMPAACT PROMISE-BF study presented at the IAC 2018.