Investigational drug AMO-02 (tideglusib) has a favourable risk-benefit and pharmacokinetic profile for congenital and childhood-onset type 1 myotonic dystrophy, a recent phase II study has shown. Further studies on tideglusib are warranted.
Children with bladder bowel dysfunction fare well with combined pelvic floor interferential electrical stimulation and muscle exercises, which can lead to a significant decrease in daytime incontinence, urgency, and constipation, as shown in a study.
In paediatric patients with microbial keratitis, the most significant risk factors are contact lens wear, trauma, and existing ocular disease, while pre-existing corneal disease and delay in presentation correlate with poor visual acuity, according to a study.
Thyroid dysfunction during pregnancy is associated with several neurocognitive outcomes in the offspring, suggest the results of a study. Prompt examination and treatment on thyroid function is urged for pregnant women.
Factors such as prolonged duration of labour, hypothermia, low birth weight, sepsis, and birth asphyxia, among others, independently contribute to an increased risk of neonatal jaundice, according to a study.
Antiviral treatment with tenofovir alafenamide fumarate (TAF) during pregnancy in highly viraemic mothers effectively prevents mother-to-child transmission (MTCT) of hepatitis B virus (HBV) with no safety concerns, according to two studies presented during the AASLD 2020 Liver Meeting.