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Paediatrics
Top Medical News
Treatment with the fully human anti-IL17 monoclonal antibody secukinumab resulted in fewer, and a longer time to, disease flares in children and adolescents with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA), results of the phase III JUNIPERA trial showed.
Treatment with COVID-19 convalescent plasma (CCP) leads to a rapid increase in antibodies and is well tolerated in paediatric patients but does not seem to interfere with immune responses measured at 21 days, results of a recent study have shown.
Prehospital antibiotic therapy (PH-ABT) leads to a marked decrease in the overall rate of bacterial pathogen detection by culture, but not by polymerase chain reaction, in children with parapneumonic pleural effusion (PPE) and pleural empyema (PE), a study has found. PH-ABT also results in a reduced rate of infectious complications but does not have an impact on the overall disease duration.
Consuming caffeinated beverages* during pregnancy – even at levels below the ACOG**-recommended daily dose of 200 mg – may lead to small reductions in neonatal anthropometric measurements, according to a secondary analysis of the NICHD*** Foetal Growth Studies-Singletons.
The web-based, time-use app My E-Diary for Activities and Lifestyle (MEDAL) is a feasible approach to capture both diet and movement behaviours in young Asian children, according to a Singapore study.
Exposures to milk leptin and adiponectin appear to have an impact on the growth of preterm infants, suggests a recent study.
Folic acid supplementation (FAS) around the time of pregnancy may help reduce the risk of nonsyndromic cleft lips or palates (NsCL/P) in offspring, a recent China study has found.
Special Reports
Ceftaroline fosamil 600 mg powder for infusion
In a webinar held on 27 March 2021, paediatric
endocrinology nurses Karen Blair,
Kate Davies, and Siti Zarina Yaakop shared
insights and clinical experience based
on their frontline roles in caring for patients
with central precocious puberty (CPP)
and supporting their family members.
Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.
Despite a 90-percent cure rate after first treatment for children with acute lymphoblastic leukaemia (ALL), approximately 10–15 percent of patients with paediatric ALL will experience relapse. [Expert Rev Anticancer Ther 2017;17:725-736] A recent webinar on the current landscape of ALL highlighted the potential of immunotherapy for paediatric patients with relapsed or refractory ALL, thus providing hope for this high-risk patient group.
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.
Rotavirus (RV) is highly contagious. Globally, 2 million children are hospitalized and more than 500,000 die annually from RV associated gastroenteritis. Therefore, vaccination is imperative for the prevention of RV infections.
Oral H1-antihistamines are the initial treatment of choice for allergic rhinitis (AR) and chronic urticaria in the primary care setting. However, in a diverse population of patients with AR and urticaria, primary care physicians are faced with the challenge of prescribing the best therapy amid a wide armamentarium of antihistamines available.
Conference Reports
Coeliac disease cases among school age children have doubled over two and a half decades, and without a wider screening strategy, most cases will remain undiagnosed, as shown in the CELI SCREEN trial.
A recent European survey has found major discrepancies and gaps in hospital policies and procedures to prevent the direct transmission of hepatitis B virus (HBV) from mother to child, particularly before and after birth.
Children whose mothers had taken fish oil supplements during the second half of pregnancy appeared to have better problem-solving skills and attention focus at age 10 vs those whose mothers had consumed folic acid alone or no supplements at all in a study presented at WCPGHAN 2021.
The addition of the monoclonal antibody dupilumab to a standard topical corticosteroid (TCS) regimen led to significant improvements in scoring AD (SCORAD*) and its components, as well as EASI** scores, in children with severe atopic dermatitis (AD), according to data from the phase III LIBERTY AD PEDS trial presented at PAS 2021.
Very low birth weight (VLBW) infants who received delayed cord clamping (DCC) for 45 seconds had a significantly higher haemoglobin (Hb) level than those who received immediate cord clamping (ICC), according to a study presented at PAS 2021.
The RNAi* therapeutic agent lumasiran demonstrated favourable clinical outcomes for primary hyperoxaluria type 1 (PH1) in both paediatric and adult patients, according to the results of the phase III ILLUMINATE-A and ILLUMINATE-B trials presented at PAS 2021.
Treatment with either low-dose (LD) or high-dose (HD) secukinumab showed continued improvement in PASI* and IGA** responses up to 24 weeks in children and adolescents with moderate-to-severe plaque psoriasis, according to updated results of a trial presented at PAS 2021.
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