osteomyelitis
OSTEOMYELITIS
Osteomyelitis is an acute or chronic inflammation of the bone due to an infection resulting from hematogenous spread, contiguous spread from soft tissues and joints to bone, or direct inoculation into bone from surgery or trauma.
The infection is generally due to a single microorganism but polymicrobial infections may also occur.
Staphylococcus aureus is a major cause of infection.
Signs and symptoms include fever; inflammatory findings of erythema, warmth, pain and swelling over the involved area; draining sinus tracts over affected bone; limited movement of affected extremity; pain in the chest, back, abdomen or leg, and tenderness over involved vertebrae in patients with vertebral osteomyelitis; anorexia, vomiting and malaise.
  1. Bader MS. Diabetic foot infection. Am Fam Physician. 2008 Jul;78(1):71-79. PMID: 18649613
  2. Calhoun JH, Manring MM. Adult osteomyelitis. Infect Dis Clin North Am. 2005 Dec;19(4):765-786. PMID: 16297731
  3. Hatzenbuehler J, Pulling TJ. Diagnosis and management of osteomyelitis. Am Fam Physician. 2011 Nov;84(9):1027-1033. Accessed 20 Sep 2013. PMID: 22046943
  4. Concia E, Napoleon P, Massari L, et al. Osteomyelitis: clinical update for practical guidelines. Nucl Med Commun. 2006 Aug;27(8):645-660. PMID: 16829765
  5. Lazzarini L, Mader JT, Calhoun JH. Osteomyelitis in long bones. J Bone Joint Surg Am. 2004 Oct(10):2305-2318. PMID: 15466746
  6. Paluska SA. Osteomyelitis. Clin Fam Pract. 2004;6(1):127-156
  7. Kaplan SL. Osteomyelitis in children. Infect Dis Clin North Am. 2005 Dec;19(4):787-797. PMID: 16297732
  8. Stengel D,Bauwens K, Sehouli J, et al. Systematic review and meta-analysis of antibiotic therapy for bone and joint infections. Lancet Infect Dis. 2001 Oct;1(3):175-188. PMID: 11871494
  9. Pineda C, Vargas A, Rodriguez AV. Imaging of osteomyelitis: current concepts. Infect Dis Clin North Am. 2006 Dec;20(4):789-825. PMID: 17118291
  10. Tice AD, Rehm SJ, Dalovisio JR et al. Practice guidelines for outpatient antimicrobial therapy. Clin Infect Dis. 2004 Jun;38(12):1651-1672. PMID: 15227610
  11. Berbari EF, Steckelberg JM, Osmon DR. Osteomyelitis. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas and Bennett’s principles and practice of infectious diseases. 6th ed. Philadelphia: Elsevier Churchill Livingstone, Inc; 2005
  12. Gutierrez KM. Osteomyelitis. In: Long SS, Pickering LK. Mandell, Douglas and Bennett’s principles and practice of infectious diseases. 3rd ed. Philadelphia: Elsevier Churchill Livingstone, Inc; 2008
  13. Daboy G. Osteomyelitis. Canale and Beaty: Campbell’s operative orthopedics. 11th ed. Philadelphia: Mosby; 2008
  14. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  15. Lalani T. Overview of osteomyelitis in adults. UpToDate. http://website.http://www.uptodate.com/contents/overview-of-osteomyelitis-in-adults. Aug 2012. Accessed 20 Sep 2013
  16. American Family Physician. Diagnosis and management of osteomyelitis. AFP. http://www.aafp.org/afp/2011/1101/p1027.html%20-%202011. Nov 2011.
  17. Fraimow H. Systemic antimicrobial therapy in osteomyelitis. Semin Plast Surg. 2009 May;23(2):90-99. doi: 10.1055/s-0029-1214161. PMID: PMC2884905
  18. Lalani T. Overview of osteomyelitis in adults. UpToDate. http://www.uptodate.com/contents/overview-of-osteomyelitis-in-adults?source=search_result&search=Osteomyelitis+in+adults&selectedTitle=1~150. Oct 2014.
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