osteoarthritis
OSTEOARTHRITIS

Osteoarthritis is a chronic progressive disease where there is degeneration & loss of articular cartilage that occurs together with new bone formation at the joint surfaces and margins, that causes pain and deformity.

The patient experiences pain, stiffness, decreased movement, inflammation and crepitus.

The pain is usually aggravated by pain and relieved by rest.

Introduction

  • A clinical syndrome of joint pain with different degrees of limitation in function & decreased quality of life
  • Most common form of arthritis
  • May not be secondary to aging & does not automatically progress
  • Process of progressive softening or localizing loss of cartilage accompanied by inadequate metabolic repair
  • Most often occurs in the hands (ends of the fingers & thumb), spine (neck & lower back), knees & hips
  • Classified as primary or secondary based on the cause or major predisposing factor; both have altered cartilage physiology
    • Primary osteoarthritis is the most common with no known cause
    • Secondary osteoarthritis has identifiable etiology but pathologically similar to primary osteoarthritis
      • Common causes are metabolic diseases (eg hemochromatosis, acromegaly), anatomic causes (eg developmental hip dislocation), trauma (joint surgery, intra-articular fractures, ligament or meniscus damage, malunion), or complication of an inflammatory disorder (septic arthritis, ankylosing spondylitis, rheumatoid arthritis & psoriatic arthritis)

Signs and Symptoms

  • Cardinal features of osteoarthritis are pain, stiffness, decreased movement, inflammation, crepitus & absence of systemic signs & symptoms like fever
    • Osteoarthritis pain is usually aggravated by activities & relieved by rest; not common to occur at night or during rest but may be experienced by patients after several hours of using joints, in advanced osteoarthritis & in acute inflammatory flare
    • Stiffness occurs in the morning lasting for a few minutes but <30 minutes, after period of rest, or in the evening which usually resolves within 10 minutes of activity

Risk Factors

Risk Factors

Age

  • >80% of individuals older than 75 years are affected; not common in patients <40 years old unless with history of trauma

Female Gender

  • Higher risk for knee osteoarthritis after menopause for unclear reasons but may be related to hormones, genetics or other undetermined factors

Genetic Predisposition

  • The influence of genetic factor varies in different subsets of osteoarthritis, ranging from 40-70%

Obesity

  • Increases risk for symptomatic & progressive osteoarthritis
    • Increases the risk for knee osteoarthritis due to the increased mechanical stress on the joints & altered joint biomechanics secondary to changes in posture, gait & level of physical activity
    • Increases stiffness in the subchondral bones & facilitates cartilage breakdown

Joint Trauma or Malalignment

  • Results in rapid development of osteoarthritis or starts the process causing symptomatic osteoarthritis later in life
  • Repetitive, high-impact sports are strongly related to joint injury which increases the risk for lower extremity osteoarthritis
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
6 days ago
Compelling evidence indicates weight bias, in which obese students appear to do less well in tertiary education than their healthy weight peers, according to a systematic review. University/college attainment appears to be less impacted by socioeconomic factors than school-based achievement.
6 days ago
Relapse following effective treatment of the first episode of schizophrenia may reduce or delay antipsychotic treatment response, a recent study has shown.
Pearl Toh, 2 days ago
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.