Osteoarthritis is a chronic progressive disease where there is degeneration and loss of articular cartilage that occurs together with new bone formation at the joint surfaces and margins that causes pain and deformity.
The patient experiences pain, stiffness, decreased movement, inflammation and crepitus.
The pain is usually aggravated by pain and relieved by rest.
Patients with knee osteoarthritis may experience better pain relief with celecoxib than with diclofenac sodium, in addition to having lower levels of inflammatory markers and complication risk, a study has found.
Treatment with subcutaneous tanezumab 5 mg yields significant improvements in pain, physical function and PGA-OA in patients with moderate-to-severe osteoarthritis (OA) who have not responded to or could not tolerate standard-of-care analgesics, according to the results of a phase III trial.
Short-term treatment (6 weeks) with 10 mg prednisolone effectively reduces finger pain and improves function in patients who have painful hand osteoarthritis (OA) coupled with signs of inflammation, the HOPE* study has shown.
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
In patients with symptomatic knee osteoarthritis (OA), the presence of knee chondrocalcinosis (CC) does not appear exert any influence on the risk of arthroplasty or disease progression at 5 years, according to a study.
The new selective cathepsin K inhibitor MIV-711 does not perform better than placebo in easing osteoarthritic pain, a study has shown. However, it substantially decreases bone and cartilage progression with a reassuring safety profile.
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.