Osteoarthritis is a chronic progressive disease where there is degeneration & loss of articular cartilage that occurs together with new bone formation at the joint surfaces and margins, that causes pain and deformity.
The patient experiences pain, stiffness, decreased movement, inflammation and crepitus.
The pain is usually aggravated by pain and relieved by rest.
Greater parity, early age at menarche, or oral contraceptive use may increase a woman’s risk of undergoing total knee replacement (TKR) for severe knee osteoarthritis (OA), according to findings from the Singapore Chinese Health Study (SCHS).
Inhibition of interleukin-1 with lutikizumab falls short in the treatment of patients with knee osteoarthritis, with the results of a phase II study showing that the drug yields limited reductions in pain without any improvement in synovitis.
Individuals with a leg that is at least 2-cm shorter than the contralateral leg are highly likely to have or develop hip osteoarthritis (OA), with the risk being greater in the shorter limb, a study has found.
Intra-articular injection with the extended release formulation of triamcinolone acetonide appears to effectively manage osteoarthritis pain with minimal blood glucose disruption in patients with concomitant knee osteoarthritis (OA) and type 2 diabetes mellitus compared with standard triamcinolone acetonide crystalline suspension, according to the results of a phase II study.
Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
Cabozantinib is not better than mitoxantrone-prednisone at relieving pain in patients with metastatic castration-resistant prostate cancer (mCRPC) with symptomatic bone metastasis, a recent study suggests.