Osteoarthritis is a chronic progressive disease where there is degeneration and loss of articular cartilage that occurs together with new bone formation at the joint surfaces and margins that causes pain and deformity.
The patient experiences pain, stiffness, decreased movement, inflammation and crepitus.
The pain is usually aggravated by pain and relieved by rest.
In patients with symptomatic knee osteoarthritis (OA), the presence of knee chondrocalcinosis (CC) does not appear exert any influence on the risk of arthroplasty or disease progression at 5 years, according to a study.
The new selective cathepsin K inhibitor MIV-711 does not perform better than placebo in easing osteoarthritic pain, a study has shown. However, it substantially decreases bone and cartilage progression with a reassuring safety profile.
Radiofrequency ablation and neuromodulation modalities for knee osteoarthritis (OA) potentially improve pain, functionality and disease-specific quality of life for up to 3–12 months with minimal localized complications, according to the results of a systematic review.
Partial knee replacement surgery provides similar clinical outcomes as total knee replacement in patients with late-stage osteoarthritis (OA), although the former proves more cost-effective according to the results of the TOPKAT* trial.
Interleukin-1 inhibition with lutikizumab does not yield substantial analgesic or anti-inflammatory effects in the treatment of patients with knee osteoarthritis (OA) and associated synovitis, with the results of a phase II trial showing limited improvement in pain and synovitis.
The antinerve growth factor fasinumab delivers significant analgesic effects in patients experiencing moderate-to-severe pain from osteoarthritis, including those benefitting little from a previous analgesic, according to the results of a phase IIB/III trial.
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.