Osteoarthritis is a chronic progressive disease where there is degeneration & loss of articular cartilage that occurs together with new bone formation at the joint surfaces and margins, that causes pain and deformity.
The patient experiences pain, stiffness, decreased movement, inflammation and crepitus.
The pain is usually aggravated by pain and relieved by rest.
Greater parity, early age at menarche, or oral contraceptive use may increase a woman’s risk of undergoing total knee replacement (TKR) for severe knee osteoarthritis (OA), according to findings from the Singapore Chinese Health Study (SCHS).
Inhibition of interleukin-1 with lutikizumab falls short in the treatment of patients with knee osteoarthritis, with the results of a phase II study showing that the drug yields limited reductions in pain without any improvement in synovitis.
Individuals with a leg that is at least 2-cm shorter than the contralateral leg are highly likely to have or develop hip osteoarthritis (OA), with the risk being greater in the shorter limb, a study has found.
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.