Early intravitreal implantation of the corticosteroid dexamethasone at an interval of ≥4 months provided rapid and significant improvement in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) in patients with macular oedema following branch retinal vein occlusion (BRVO), according to the COBALT* study.
The prostaglandin analogue latanoprost demonstrates an acceptable safety profile in the long-term treatment of paediatric patients with glaucoma and ocular hypertension, with no evidence of clinically meaningful changes in ocular development or hyperpigmentation, according to the results of a 3-year safety study of the drug.
Young adults born extremely preterm exhibit considerable structural alterations at the fovea, a study has shown. Increased ganglion cell layer thickness is associated with poor best-corrected visual acuity (BVCA), with retinal layer thickness and BCVA being profoundly affected in eyes requiring neonatal treatment for retinopathy of prematurity.
applications approved by US FDA as of 1 - 15 September 2018 which includes New Molecular Entities (NMEs) and new
biologics. It does not include Tentative Approvals. Supplemental approvals
may have occurred since the original approval date.
Long-term treatment with memantine is well tolerated but does not effectively prevent glaucomatous progression in patients with open-angle glaucoma (OAG), according to the results of two phase III trials.
Use of unwrapped, short-cycle sterilization adhering to the manufacturers’ instruction for use (IFU) of two popular sterilizers is effective for sequential same-day cataract procedures, a study has shown.
In Asia, infectious keratitis occurs predominantly in males and is frequently associated with trauma, according to data from the Asia Cornea Society Infectious Keratitis study (ACSIKS). Visual acuity following infection may be poor, and corneal transplantation for active disease is associated with a high failure rate.
Administering conbercept at a dose of 0.5 mg once monthly for the first 3 months then once quarterly until month 12 appears to be effective in the treatment of age-related macular degeneration, with significant improvements in visual acuity observed at month 3 and maintained through 1 year, according to the results of the phase III PHOENIX trial.
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.