The addition of the fluoroquinolone levofloxacin to myeloma therapy during the first 12 weeks led to a significant reduction in febrile episodes and deaths compared with placebo, suggesting that levofloxacin prophylaxis could be a standard of care in the first 3 months following myeloma diagnosis to prevent infection, according to a British study.
The addition of radiofrequency ablation (RFA) or high-dose radiotherapy (RT) to accompany transcatheter arterial chemoembolization (TACE) may improve the overall survival rates of patients with hepatocellular carcinoma (HCC) versus TACE alone.
Crizotinib proves to be effective against nonsmall-cell lung cancer (NSCLC) with ROS-1 translocations and has modest activity in c-MET >6 copies and c-MET mutations, according to the results of the phase II AcSé trial.
An association exists between cribriform pattern with intraductal carcinoma and adverse outcomes in men with Gleason 7 prostate cancer treated with external beam radiotherapy, reports a study. Cribriform pattern without intraductal carcinoma shows no association.
The phase II AMN001* trial conducted by the Asian Myeloma Network confirmed the efficacy of a pomalidomide plus dexamethasone regimen in Asian patients with relapsed/refractory multiple myeloma (RRMM), with a potential added benefit following the addition of cyclophosphamide.
Concurrent chemoradiotherapy (CCRT) appeared to improve survival rates in patients with locoregionally advanced nasopharyngeal carcinoma (NPC), according to a systematic review and meta-analysis, with a potential benefit noted with the addition of induction chemotherapy.