The trastuzumab biosimilar HLX02 was equivalent to the reference trastuzumab in terms of overall response rate (ORR) in women with HER2*-positive (HER2+) breast cancer, along with similar safety profile, reveals a study presented at ESMO Asia 2019.
Patients with advanced or metastatic renal cell carcinoma (RCC) who have not previously received treatment with vascular endothelial growth factor-tyrosine kinase inhibitors (VEGF-TKIs) may potentially benefit from treatment with the TKI pazopanib, according to interim analysis results of the PARACHUTE* trial presented at ESMO Asia 2019.
The combination of the aromatase inhibitor letrozole plus the Src kinase inhibitor dasatinib appears to be well tolerated and effective, with a clinical benefit rate of 71 percent in a cohort of postmenopausal patients with ER-positive, HER2-negative metastatic breast cancer, according to the results of a noncomparative phase II trial.
In India, nearly one in four unselected ovarian cancer patients present with germline pathogenic BRCA1/BRCA2 mutations, of whom 85 percent had no discernible family history of breast or ovarian cancer, according to a study presented at the recent 2019 Asia Congress of the European Society for Medical Oncology (ESMO Asia 2019).
Incorporating basic tumour characteristics, such as hormone receptor status and tumour origin, improves the power of the cell-loss metric to predict response to treatment, according to a new study presented at the recently concluded 2019 Asia Congress of the European Society for Medical Oncology (ESMO Asia 2019).
Treatment of non-small-cell lung cancer (NSCLC) provides significant overall survival (OS) benefit in patients aged ≥90 years and should not be withheld based on old age alone, according to an analysis of data from the US National Cancer Database.
Pushing genetic counselling into the mainstream through nongenetics clinicians, such as oncologists, appears to improve the uptake of genetic testing in ovarian cancer in Malaysia and marginally reduce distress and cancer worry among patients, according to data from the MAGIC* study presented at the ESMO Asia 2019 Congress.
The combination of the PD-L1* inhibitor atezolizumab and the VEGF** inhibitor bevacizumab gains the upper hand over sorafenib in the treatment of unresectable hepatocellular carcinoma (HCC), according to the results of the phase III IMbrave150*** trial presented at ESMO Asia 2019.
Adding pembrolizumab to platinum-based chemotherapy significantly improved survival and response to treatment compared with chemotherapy alone in the first-line setting for Chinese patients with metastatic, squamous non–small-cell lung cancer (NSCLC), according to the KEYNOTE-407* China Extension Study presented at the ESMO Asia 2019 Congress.
In breast cancer, especially hormone-negative tumours, an ultrasound-guided core biopsy (CNB) is useful for predicting pathologic complete response (pCR) to chemotherapy and may thus help to avoid surgery for some patients, a study has found.
Dr. Jay Zhu, Dr. Lai Fung Li, Prof. Chae-Yong Kim,
27 Nov 2019
The current standard
of care for glioblastoma multiforme (GBM), an aggressive primary brain tumour
with a rapid disease course, consists of maximum safe surgical resection
followed by radiotherapy with concomitant temozolomide (TMZ) chemotherapy and
subsequent TMZ maintenance. At the 16th Annual Meeting of the Asian
Society of Neuro-Oncology (ASNO) in Taipei, Taiwan, experts reviewed the
evidence and shared their clinical experience on the use of tumour treating
fields (TTFields), a novel treatment modality for GBM.
There appears to be no significant survival difference between first-line immune checkpoint inhibitor (ICI) and carboplatin-based chemotherapy in cisplatin-ineligible metastatic urothelial carcinoma patients, according to a Taiwan study presented at the recent 2019 Asia Congress of the European Society for Medical Oncology (ESMO Asia 2019).