The effectiveness and haematologic toxicity of a carboplatin-based chemotherapy are similar to those of cisplatin in the adjuvant treatment of resected nonsmall cell lung cancer (NSCLC), according to a study.
Patients with advanced non-small-cell lung cancer (NSCLC) and brain metastases demonstrated better progression-free survival (PFS) when initiating the oral EGFR* TKI** afatinib at a higher rather than a lower dose, according to a retrospective study from Singapore.
Overall, the risk of lung cancer is higher in former and current smokers with higher concentrations of high sensitivity C-reactive protein (hsCRP), according to a study. Additionally, circulating hsCRP is not associated with the risk of lung adenocarcinoma and may reflect a prediagnostic disease state rather than a causal risk for lung cancer.
Frailty predicts toxicity during the first cycle of chemotherapy in elderly adults with nonsmall cell lung cancer (NSCLC), a recent study has shown. Relevant assessments may be used to evaluate toxicity risk regardless of chronologic age.
Among patients with inflammatory bowel disease (IBD), older age at the time of IBD diagnosis and longer disease duration are associated with a heightened risk of developing colitis-associated neoplasia, a study has found.
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.