Use of zoledronic acid for 2 years appears to be effective against cancer treatment-induced bone loss in premenopausal women with breast cancer, with bone mass density values maintained for up to 3 years after cessation of treatment, according to the results of the placebo-controlled ProBone II trial.
Neoadjuvant chemoradiotherapy (CRT) is still the standard of care for locally advanced rectal cancer in a local population, according to a Singapore study, adding that outcomes are similar to international published data.
Adding bevacizumab to platinum-based chemotherapy significantly improves progression-free survival (PFS) in patients with recurrent ovarian cancer who were previously treated with first-line bevacizumab, according to the MITO16B - MaNGO OV2B - ENGOT OV17* study presented at ASCO 2018.
The use of ethanol lock therapy did not reduce treatment failure of central line-associated bloodstream infections (CLABSIs) in patients with cancer or haematological disorders, but was associated with an increased risk of catheter occlusion, a recent study found.
Treatment with pembrolizumab results in durable antitumour activity, high survival rates and acceptable safety in patients with heavily pretreated advanced head and neck squamous cell carcinoma (HNSCC), a recent study has shown.
The addition of the EGFR inhibitor nimotuzumab to a chemoradiotherapy (CRT) regimen using cisplatin improved progression-free survival (PFS) and disease-free survival (DFS) in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) compared with CRT alone, according to data from a phase III trial presented at ASCO 2018.
Patients with metastatic clear-cell renal cell carcinoma (mRCC) who received sunitinib appeared to have comparable overall survival (OS) with those who received sunitinib after undergoing cytoreductive nephrectomy, according to the phase III CARMENA* trial.
Long-term aspirin use appears to significantly lower the risk of gastric cancer when taken at a cumulative dose of >3 defined daily dose (DDD)-years, according to a recent population-based and longitudinal South Korea study.
Matching targeted therapy to genetic alterations in the tumour improved response rate and long-term survival in patients with advanced cancer who underwent molecular profiling compared with patients who were unmatched to therapy, highlighting the role of molecular testing in precision medicine, the IMPACT* study shows.
In a symposium chaired by Dr Yoon-Sim Yap of the National Cancer Centre Singapore, renowned regional and international experts in the field of breast cancer, Dr Yen-Shen Lu from Taiwan and Professor Nadia Harbeck from Germany, joined her in providing insights on the current treatment landscape of hormone receptor-positive (HR+) advanced breast cancer. In their respective sessions, they each highlighted new therapeutic options including the optimal use of dual blockade therapy for oestrogenreceptor-positive (ER+) advanced breast cancer for patients in Asia.