Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
The combination of the monoclonal antibody pembrolizumab and a chemotherapy (CT) regimen consisting of S-1 plus oxaliplatin (SOX) showed encouraging efficacy and manageable safety as first-line treatment in patients with advanced gastric/gastroesophageal junction (G/GEJ) cancer, according to the cohort 1 results of the Japanese KEYNOTE-659* study.
The combination of olaparib and bevacizumab as maintenance therapy for advanced ovarian cancer appears to confer the greatest progression-free survival (PFS) benefit in women without residual macroscopic disease following upfront cytoreductive surgery, according to an analysis of the phase III PAOLA-1* trial.
The investigational, oral GnRH* receptor antagonist relugolix effectively and rapidly reduced and sustained testosterone to castration levels while exhibiting a favourable safety profile in men with prostate cancer (PCa), a phase II trial has shown.
New drug applications approved by US FDA as of 01 - 15 May 2020 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
The PARP* inhibitor niraparib improves progression-free survival (PFS) and is well-tolerated in women with newly diagnosed advanced ovarian cancer (OCa) after a response to first-line (1L) platinum-based chemotherapy (CT), subgroup results of the phase III PRIMA/ENGOT-OV26/GOG-3012 trial have shown.
Head and neck cancers encompass a wide spectrum of disease, ranging from carcinomas of the upper aerodigestive tract (oral cavity, pharynx, larynx), to tumours of the skin and salivary glands, to sinonasal malignancies.
The immune checkpoint inhibitor nivolumab yields long-term overall survival (OS) gains in treatment-experienced patients with gastric/gastroesophageal junction (G/GEJ), with the benefit most pronounced among those who show a complete (CR) or partial response (PR), according to the 2-year follow-up results of the phase III ATTRACTION-2a study.
The oral PARP inhibitor talazoparib significantly improves patient-reported outcomes (PROs), but not overall survival (OS), compared with physician’s choice of chemotherapy (PCT) in patients with locally advanced or metastatic HER2-negative breast cancer with a germline BRCA1/2 mutation, final results of the phase III EMBRACA trial have shown.
A blood test is shown to be feasible and safe for early detection of multiple cancers in women with no current or known history of cancer, enabling early treatment with curative intent in a subset of individuals.
Patients with advanced non-small-cell lung cancer (NSCLC) who have a past medical history of pneumonitis are at increased risk of treatment-related pneumonitis (TAP) from immune checkpoint inhibitor (ICI) regimens or chemotherapy alone, an analysis of clinical trial and real-world data has shown.
Pembrolizumab monotherapy improves overall
survival (OS) and cancer control compared with platinum-based chemotherapy in
patients with untreated locally advanced or metastatic programmed death-ligand
1 (PD-L1)–positive non-small-cell lung cancer (NSCLC) regardless of STK11
or KEAP1 mutation status, according to results of the phase III