A novel polygenic hazard score adapted to different genetic ancestries can be used for reliable risk-stratification among prostate cancer patients across multiple ethnicities, a recent study has found.
Achalasia is associated with an increased risk of developing both squamous cell carcinoma and adenocarcinoma of the oesophagus, reveals a study, noting, however, that the annual incidence of oesophageal cancer is rather low.
Survival is worse among patients with advanced BRAFV600 wild-type melanoma than those with BRAFV600-mutant advanced melanoma during the first 10 months following diagnosis due to limited treatment options, according to a Dutch study.
Supplementation with pancreatic enzymes results in symptomatic recovery in hepatocellular carcinoma (HCC), as shown in a study that validated the association between malabsorption (MA) and pancreatic insufficiency (PI) in 10 percent of sorafenib-treated patients.
In patients with advanced medullary thyroid cancer, treatment with vandetanib in the first- or second-line setting provides sustained clinical benefit, with predictors of durable response including younger age at diagnosis and absence of progression, according to a study.
Pre-existing diabetes in mothers, but not that which developed during pregnancy, appears to contribute to a heightened risk of childhood cancer in the offspring, particularly acute lymphoblastic leukaemia, according to a systematic review and meta-analysis.
The effectiveness of programmed cell death protein 1 or its ligand (L1) inhibitors is similar as regards time to initiation of third therapy or death and overall survival in patients with platinum refractory locally advanced/unresectable or metastatic urothelial carcinoma, a recent study has shown.