The combination of bevacizumab plus trabectedin (BT) shows promising clinical activity with limited toxicity in the treatment of women with partially platinum-sensitive ovarian cancer, according to the results of a phase II study. A regimen consisting of BT plus carboplatin also has good activity although with relatively increased toxicity.
Using a humanized antidisialoganglioside mAb (hu14.18K322A) in combination with induction chemotherapy appears to yield favourable outcomes in children with high-risk neuroblastoma, including induction of an early response, improvement of Curie scores (CSs) and a 2-year event-free survival (EFS), according to the results of a phase II trial.
While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.
Use of oestrogen therapy alone appears to contribute to an increased risk of developing cutaneous melanoma, although the addition of progestins may counteract this unfavourable effect, a study has found.
Use of fludarabine cytarabine and granulocyte colony stimulating factor with or without idarubicin (FLAG ± IDA) leads to a 69-percent rate of complete remission in children with relapsed/refractory acute leukaemia, but only 48 percent of patients survive to bone marrow transplantation, a study has shown.
Final analysis of the POEMS (Prevention of Early Menopause) study finds that breast cancer (BC) patients treated with the gonadotrophin-releasing hormone agonist (GnRHa) goserelin, in addition to chemotherapy, are more likely to avoid premature menopause and to become pregnant without negatively impacting disease-related outcomes.
In breast cancer, especially hormone-negative tumours, an ultrasound-guided core biopsy (CNB) is useful for predicting pathologic complete response (pCR) to chemotherapy and may thus help to avoid surgery for some patients, a study has found.
Circulating miR-155 may be potentially used as a diagnostic and therapeutic monitoring marker in breast cancer, suggests an Indonesian study presented at the 2019 Asia Congress of the European Society for Medical Oncology (ESMO Asia 2019).