Selective internal radiation therapy (SIRT) with yttrium-90 resin microspheres does not improve overall survival (OS) vs sorafenib in patients with locally advanced hepatocellular carcinoma (HCC), although it significantly improves tumour response and reduces adverse events (AEs), the phase III SARAH study has shown.
In patients with liver-only or liver-dominant metastatic colorectal cancer (mCRC) with right-sided primary tumours, addition of selective internal radiation therapy (SIRT) to first-line mFOLFOX6 chemotherapy significantly improves overall survival (OS), according to results of a study presented at the European Society for Medical Oncology (ESMO) 19th World Congress on Gastrointestinal Cancer (WCGC 2017) held in Barcelona, Spain.
Liquid biopsy at disease progression effectively identifies novel and heterogeneous mechanisms of acquired resistance to targeted therapies in patients with a range of gastrointestinal (GI) cancers, which may help guide subsequent therapy.
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Final analysis of the POEMS (Prevention of Early Menopause) study finds that breast cancer (BC) patients treated with the gonadotrophin-releasing hormone agonist (GnRHa) goserelin, in addition to chemotherapy, are more likely to avoid premature menopause and to become pregnant without negatively impacting disease-related outcomes.
In breast cancer, especially hormone-negative tumours, an ultrasound-guided core biopsy (CNB) is useful for predicting pathologic complete response (pCR) to chemotherapy and may thus help to avoid surgery for some patients, a study has found.
A 70-month prospective study in Southern Chinese women, sponsored by the World Cancer Research Fund, finds no evidence of pre-diagnosis soy intake negatively affecting mortality or recurrence among breast cancer survivors. On the contrary, the results indicate that moderate soy intake may be associated with better outcomes.