Patients with coronavirus disease 2019 (COVID-19) who have haematologic malignancies have a 28 percent mortality rate, according to data collected from 250 patients by the ASH Research Collaborative COVID-19 presented at the 62nd American Society of Hematology Annual Meeting and Exposition (ASH 2020).
In patients newly diagnosed with immune thrombocytopenia (ITP), the first-line combination treatment of mycophenolate and corticosteroids was effective and well tolerated compared with corticosteroids alone, results of the UK-based Flight* trial showed.
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.
An anticoagulation strategy based on blood D-dimer level as a biomarker for clotting risk may help improve survival of patients hospitalized with COVID-19, according to a study presented during the ASH 2020 Meeting.
Dabigatran was similarly effective as standard of care (SOC) in resolving thrombus and preventing recurrent venous thromboembolism (VTE), without raising the risk of bleeding in children, according to the DIVERSITY trial presented at ASH 2020 — thus providing a potential oral alternative to standard of care for the paediatric population.
The combination of panobinostat, dexamethasone, and subcutaneous (SC) bortezomib shows promising responses in patients with relapsed or relapsed and refractory multiple myeloma (RRMM), according to the phase II PANORAMA 3* study. Furthermore, SC bortezomib may be preferable to the intravenous (IV) option for reducing toxicity.
Patients with chronic lymphocytic leukaemia (CLL)/small lymphocytic lymphoma (SLL) who achieve undetectable minimal residual disease (uMRD) in peripheral blood (PB) and bone marrow (BM) after 12 cycles of first-line treatment with ibrutinib plus venetoclax have similar 1-year disease-free survival (DFS) rates regardless of whether ibrutinib is continued or not, results of the phase II CAPTIVATE study have shown.
Combining the anti-PD-1 antibody sintilimab and a bevacizumab biosimilar significantly improves survival compared with the standard treatment of sorafenib in the first-line setting for patients with advanced, unresectable hepatocellular carcinoma (HCC), according to the ORIENT-32 study presented at ESMO Asia 2020.