Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
The addition of daratumumab to a bortezomib-melphalan-prednisone (VMP) regimen appears to improve progression-free survival (PFS) over VMP alone in individuals newly diagnosed with multiple myeloma who are ineligible for stem-cell transplantation, according to findings from the phase III ALCYONE* trial.
The use of lenalidomide plus rituximab may improve progression-free survival (PFS) and overall survival (OS) rates in patients with mantle cell lymphoma (MCL), according to a study presented at ASH 2017.
Patients with relapsed/refractory chronic lymphocytic leukaemia (CLL) given a combination of venetoclax and rituximab (VR) demonstrated superior progression-free survival (PFS) over those given bendamustine plus rituximab (BR), a finding which positions VR as a potential new therapeutic option for relapsed/refractory CLL, the phase III MURANO trial shows.
Adding the immunotherapy abatacept to standard drug regimen used for preventing graft-versus-host disease (GvHD) significantly reduced, and almost eliminated, life-threatening severe acute GvHD in patients undergoing haematopoietic stem cell transplants.
Professor Robert Brodsky from Johns Hopkins University
School of Medicine, and Secretary of ASH, details findings of four of the
late-breaking trials: Hokusai VTE-Cancer (dalteparin), Murano (venetoclax),
Alcyone (daratumumab), and Hercules (caplacizumab) trials.
Professor Gary Raskob from the College of Public Health,
University of Oklahoma, Oklahoma City, US speaks about the efficacy and safety
of dalteparin vs low-molecular-weight heparin/edoxaban for venous
thromboembolism in patients with cancer.
Adolescent and young adult (AYA) patients treated for acute lymphoblastic leukaemia (ALL) were more likely to have an increased rate of toxicities in every organ system compared with children, according to a study presented at ASH 2017.
Rituximab maintenance following first-line immunotherapy with R-CHOP* is highly effective for mantle cell lymphoma (MCL), with prolonged progression-free survival (PFS) and overall survival (OS) rates compared with interferon-alpha maintenance, according to the long-term follow-up results of the European MCL Elderly trial presented at ASH 2017.
The noninferiority of edoxaban compared with dalteparin in preventing recurrent venous thromboembolism (VTE) and major bleeding in patients with cancer highlights edoxaban as a potential alternative to low molecular weight heparin (LMWH) in this group of patients, suggests results of the Hokusai VTE-Cancer Study presented at ASH 2017.
A blood test is shown to be feasible and safe for early detection of multiple cancers in women with no current or known history of cancer, enabling early treatment with curative intent in a subset of individuals.
Hippocampal avoidance during whole-brain radiotherapy (HA-WBRT), together with memantine, better preserves cognitive function vs WBRT plus memantine in patients with brain metastases, without compromising survival, a multi-institutional phase III trial has shown.
Cancer patients infected with coronavirus disease 2019 (COVID-19) appear to be at higher risk of severe outcomes, including death, but cancer type and treatment serve as better predictors, according to recent research presented at the American Association for Cancer Research (AACR) 2020 Virtual Annual Meeting I.
At the time of writing, COVID-19 has spread to more than 200 countries and territories, affecting an estimated 4.5 million people and killing over 300,000. Cancer, on the other hand, is newly diagnosed in 18 million people and takes the lives of 10 million every year.
“We have invited physician scientists who are at the epicentre of the COVID-19 pandemic, taking care of patients with cancer. They gathered prospective information to understand the effects of COVID-19 on patients with cancer, are testing new treatments, and are making this knowledge available to the global research community, so we can all benefit from their experience,” said Professor Antoni Ribas from UCLA Medical Center, Los Angeles, California, US, chairperson of the COVID-19 and cancer plenary session of the meeting.
Fasting-mimicking diet (FMD) cycles in combination with endocrine therapy (ET) cause metabolic changes in hormone receptor (HR)-positive breast cancer patients analogous to those observed in animal models, where they are associated with anticancer activity.