Dr. Hang Wun Raymond Li, Prof. Pak-Chung Ho, Dr. Ernest Hung Yu Ng, 20200317000000
Anti-Müllerian hormone (AMH) was initially recognized as the factor that
determines regression of the Müllerian duct in the male foetus and
hence plays an important role in male sex differentiation. Production of
AMH in adult women was first reported in 1990.1 In the past two
decades, its role in female ovarian function and the clinical utilities
of serum AMH level has been increasingly studied.
Dr. Daniel Chan, Assoc Prof. Daisy Kwai-Lin Chan, 20200312000000
Hypoglycaemia is one of the most common clinical issues facing newborn
babies. It can be caused by abnormalities in the glycogen stores,
alternative substrates, and/or functioning enzymes. The definition of
neonatal hypoglycaemia itself remains challenging. Understanding normal
glucose physiology and biochemistry is important so that the
neonatologist can initiate appropriate investigations to elucidate an
aetiology and institute correct management. Early diagnosis and prompt
treatment of hypoglycaemia will reduce the risk of brain injury to the
Dr. Kubi Appiah, Dr. Piya Chaemsaithong, Dr. Liona Chiu Yee Poon, 20191129085839
Preterm birth (PTB) is birth that occurs before 37 weeks’ gestation, and it is a leading cause of perinatal morbidity and mortality.1 Babies born before 34 weeks’ gestation are particularly associated with high rates of morbidity and mortality.2 They are also at risk of long-term medical and social sequelae.3 It is therefore important to institute preventative measures that can help mitigate the occurrence of PTB in pregnant women.
Dr. Xian Li, Dr. Hang Wun Raymond Li, Dr. Shui Hua Lin, Prof. Pak-Chung Ho, 20190312084537
Endometrial polyp (EP) is a frequently encountered gynaecologic condition that may present with abnormal vaginal bleeding. It can also be asymptomatic and detected incidentally during imaging investigations or hysteroscopy for infertility or other conditions. Most EPs are benign, but premalignancy or even malignancy may occasionally occur.
Teng Sung Shin, Joyce Lam Ching Mei, 20180903000000
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Genetic diseases cause great physical effect to newborns and psychological impact to parents. Recessive genetic diseases can hit asymptomatic carrier couples with detrimental impact because very often they are not aware of their carrier status. Recessive genetic disease affects at least 30 in every 1,000 children, ranging from very mild to severe phenotype.1-2 Common examples of recessive genetic diseases include thalassaemia, spinal muscular atrophy, congenital adrenal hyperplasia, cystic ﬁbrosis, among others.
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Adding the CDK4/6 inhibitor abemaciclib to an endocrine therapy of fulvestrant extends overall survival (OS) compared with fulvestrant alone in East Asian patients with hormone receptor-positive (HR+), HER2-negative advanced breast cancer (ABC) who have progressed on prior endocrine therapy, consistent with results from the overall population, updated analysis of the global, phase III MONARCH 2 study has shown.